Amovix
Generic Name
Amoxicillin
Manufacturer
Opsonin Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amovix 250 mg tablet | ৳ 25.00 | ৳ 150.00 |
Description
Overview of the medicine
Amoxicillin is a penicillin-type antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu).
Uses & Indications
Dosage
Adults
General dosage: 250 mg to 500 mg every 8 hours, or 750 mg to 1 g twice daily, depending on the severity and type of infection. Higher doses may be used for severe infections.
Elderly
Similar to adults, but dosage adjustment may be necessary if renal function is impaired. Consult a physician.
Renal_impairment
Dosage reduction is required. For creatinine clearance less than 30 mL/min, the dose interval should be increased or the dose reduced. Consult a physician for specific recommendations.
How to Take
Take Amovix tablets orally with a glass of water, with or without food. It is recommended to take it at evenly spaced intervals. Do not crush or chew the tablet; swallow it whole.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, thus inhibiting cell wall biosynthesis. This leads to the lysis and death of bacterial cells.
Pharmacokinetics
Onset
Clinical effects usually seen within a few hours to days, depending on the infection type and severity.
Excretion
Primarily excreted unchanged in the urine by active tubular secretion and glomerular filtration. Renal clearance accounts for 60-80% of total clearance.
Half life
Approximately 1 to 1.5 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, even in the presence of food. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Approximately 10-25% of an oral dose is metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to amoxicillin, any other penicillin, or to any of the excipients.
- History of severe immediate hypersensitivity reaction to another beta-lactam agent (e.g., cephalosporin, carbapenem or monobactam).
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels by decreasing renal tubular secretion.
Allopurinol
Concomitant use may increase the incidence of skin rashes.
Methotrexate
Amoxicillin may reduce the renal excretion of methotrexate, increasing its toxicity.
Oral Contraceptives
May decrease the efficacy of oral contraceptives (rarely reported).
Oral Anticoagulants (e.g., Warfarin)
May prolong prothrombin time; INR monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and fluid and electrolyte imbalance. In cases of very high doses, crystalluria leading to renal failure has been reported. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered soon after ingestion. Hemodialysis can be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy: Category B. Amoxicillin has been widely used in pregnancy and is considered generally safe. Use only if clearly needed. Lactation: Amoxicillin is excreted in breast milk in small amounts. Generally considered compatible with breastfeeding, but monitor the infant for diarrhea, candidiasis, or allergic reactions.
Side Effects
Contraindications
- Known hypersensitivity to amoxicillin, any other penicillin, or to any of the excipients.
- History of severe immediate hypersensitivity reaction to another beta-lactam agent (e.g., cephalosporin, carbapenem or monobactam).
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels by decreasing renal tubular secretion.
Allopurinol
Concomitant use may increase the incidence of skin rashes.
Methotrexate
Amoxicillin may reduce the renal excretion of methotrexate, increasing its toxicity.
Oral Contraceptives
May decrease the efficacy of oral contraceptives (rarely reported).
Oral Anticoagulants (e.g., Warfarin)
May prolong prothrombin time; INR monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and fluid and electrolyte imbalance. In cases of very high doses, crystalluria leading to renal failure has been reported. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered soon after ingestion. Hemodialysis can be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy: Category B. Amoxicillin has been widely used in pregnancy and is considered generally safe. Use only if clearly needed. Lactation: Amoxicillin is excreted in breast milk in small amounts. Generally considered compatible with breastfeeding, but monitor the infant for diarrhea, candidiasis, or allergic reactions.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, consult package for exact date.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Amoxicillin has undergone extensive clinical trials since its introduction, establishing its efficacy and safety profile across a wide range of bacterial infections. Ongoing research focuses on resistance patterns and optimal dosing strategies.
Lab Monitoring
- For prolonged therapy, periodic assessment of renal, hepatic, and hematopoietic function is recommended.
- In patients with renal impairment, monitor renal function (e.g., creatinine clearance).
- Monitor INR/prothrombin time in patients concomitantly receiving oral anticoagulants.
Doctor Notes
- Prescribe based on bacterial susceptibility patterns whenever possible.
- Advise patients on the importance of completing the full course to prevent resistance.
- Be aware of potential hypersensitivity reactions, especially in patients with a history of penicillin allergy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if symptoms improve.
- Do not share your medication with others or use it for other infections.
- Inform your doctor if you experience severe diarrhea, rash, or any other unusual symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Amoxicillin generally does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should exercise caution.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated by drinking plenty of fluids.
- Avoid self-medication with antibiotics.
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