Ancef
Generic Name
Cefazolin
Manufacturer
GlaxoSmithKline (GSK)
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ancef 125 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Cefazolin is a first-generation cephalosporin antibiotic used to treat various bacterial infections. It works by inhibiting bacterial cell wall synthesis.
Uses & Indications
Dosage
Adults
This 125 mg suspension is primarily for children. Pediatric dosage: 25-50 mg/kg/day divided into 3-4 doses. Max 100 mg/kg/day. Typically 125 mg (5 mL) every 6-8 hours, depending on weight and infection severity.
Elderly
Dosage adjustment not usually required unless renal impairment is present.
Renal_impairment
Dosage reduction required based on creatinine clearance.
How to Take
Oral administration. Shake well before use. Can be taken with or without food. Complete the full course of medication.
Mechanism of Action
Cefazolin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within 30 minutes to 1 hour after administration.
Excretion
Primarily via renal excretion (glomerular filtration and tubular secretion).
Half life
Approximately 1.8 hours.
Absorption
Well absorbed orally for pediatric formulations, though usually administered IV/IM in adults. Peak plasma concentrations reached within 1-2 hours after oral administration.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to cefazolin, other cephalosporins, or penicillins.
- •History of severe allergic reaction to penicillin.
Drug Interactions
Probenecid
May increase cefazolin levels.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effect (rare).
Nephrotoxic drugs (e.g., Aminoglycosides)
May increase risk of nephrotoxicity.
Storage
Store dry powder at room temperature (below 30°C). Reconstituted suspension should be refrigerated (2-8°C) and discarded after specified days (e.g., 14 days).
Overdose
Supportive care and symptomatic treatment. Hemodialysis may be helpful.
Pregnancy & Lactation
Generally considered safe. Use with caution, weigh benefits against risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Varies by manufacturer, typically 1-2 years unopened. Once reconstituted, typically 7-14 days refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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