Adults

Typical oral dosage for moderate infections: 250 mg to 1 gram every 6-8 hours. For severe infections, dosage may be increased.

Elderly

Dosage adjustment may be required based on renal function, typically lower doses or extended dosing intervals.

Renal_impairment

Reduced dosage frequency or amount is necessary based on creatinine clearance. Consult a physician for specific guidelines.

Onset

Rapid, typically within 1-2 hours of an oral dose.

Excretion

Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion. About 60-70% of the dose is excreted within 6 hours.

Half life

Approximately 1.8 hours in adults with normal renal function.

Absorption

Well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Minimally metabolized; less than 20% of the dose undergoes metabolism.

Probenecid

Concomitant administration with probenecid decreases the renal tubular secretion of cefazolin, resulting in increased and prolonged plasma concentrations of cefazolin.

Oral anticoagulants (e.g., warfarin)

May enhance the anticoagulant effect by interfering with vitamin K synthesis in the gut. Monitor INR levels.

Nephrotoxic drugs (e.g., aminoglycosides, furosemide)

Concurrent use may increase the risk of nephrotoxicity. Monitor renal function closely.