Aponia
Generic Name
Aponia Hydrochloride
Manufacturer
Medicon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aponia 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Aponia 500 mg Tablet is a non-opioid analgesic and antipyretic medication used for symptomatic relief of mild to moderate pain and fever. It contains Aponia Hydrochloride as the active ingredient.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed. Maximum daily dose 4000 mg (4 tablets).
Elderly
Same as adults, but caution for renal impairment. Dose adjustment may be required.
Renal_impairment
Creatinine clearance 10-50 mL/min: dose interval of 6 hours. Creatinine clearance <10 mL/min: dose interval of 8 hours.
How to Take
Oral. Can be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Aponia primarily acts by inhibiting prostaglandin synthesis in the central nervous system (CNS) and to a lesser extent, peripherally. It produces analgesia by elevating the pain threshold and antipyresis through its action on the hypothalamic heat-regulating center.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Excreted predominantly in the urine as glucuronide and sulfate conjugates; less than 5% is excreted unchanged.
Half life
2-3 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract, peak plasma concentrations reached within 30-60 minutes.
Metabolism
Primarily metabolized in the liver, mainly through glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 to a reactive intermediate (NAPQI), which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Aponia or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity with chronic heavy alcohol use.
Warfarin
May enhance the anticoagulant effect of warfarin with prolonged use, increasing risk of bleeding.
Other hepatotoxic drugs
Increases the risk of liver damage.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage (jaundice, liver tenderness) in severe cases. Antidote is N-acetylcysteine. Seek immediate medical attention.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor. Use the lowest effective dose for the shortest duration.
Side Effects
Contraindications
- Hypersensitivity to Aponia or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity with chronic heavy alcohol use.
Warfarin
May enhance the anticoagulant effect of warfarin with prolonged use, increasing risk of bleeding.
Other hepatotoxic drugs
Increases the risk of liver damage.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage (jaundice, liver tenderness) in severe cases. Antidote is N-acetylcysteine. Seek immediate medical attention.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor. Use the lowest effective dose for the shortest duration.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent expired, generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials demonstrated efficacy and safety for mild to moderate pain and fever relief, confirming its role as a first-line agent.
Lab Monitoring
- Liver function tests (ALT, AST) if used long-term or in cases of suspected overdose
- Renal function tests (creatinine, BUN) in patients with renal impairment
Doctor Notes
- Advise patients on maximum daily dose to prevent liver toxicity.
- Consider renal function in elderly and renally impaired patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid concomitant use with other Aponia-containing products.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Aponia is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid these activities.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption while on medication, especially if prone to liver issues.
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Global Brand Names
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