Aponia
Generic Name
Naproxen
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aponia 750 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Aponia 750 mg Tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and fever. It is commonly prescribed for conditions like arthritis, menstrual pain, and muscle aches.
Uses & Indications
Dosage
Adults
For various conditions, typically 750 mg once daily or 375 mg twice daily for an extended-release formulation. Doses may be adjusted based on condition and response, up to a maximum of 1500 mg/day for short-term use.
Elderly
Use lowest effective dose. Increased risk of adverse effects, especially GI bleeding and renal impairment. Monitor renal function.
Renal_impairment
Use with caution; consider dose reduction. Contraindicated in severe renal impairment (CrCl < 30 mL/min).
How to Take
Take Aponia 750 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole; do not crush, chew, or break it if it is an extended-release formulation.
Mechanism of Action
Naproxen works by inhibiting the synthesis of prostaglandins, which are chemicals in the body that contribute to pain, inflammation, and fever. It primarily inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes.
Pharmacokinetics
Onset
Within 1 hour for pain relief, longer for full anti-inflammatory effect.
Excretion
Excreted primarily in the urine (approximately 95%) as unchanged drug, 6-O-desmethylnaproxen, or their conjugates.
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver to 6-O-desmethylnaproxen, mainly via CYP2C9.
Side Effects
Contraindications
- Known hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma, urticaria, or allergic reactions)
- Active or history of recurrent peptic ulcer/hemorrhage
- Severe heart failure
- Severe renal impairment (CrCl < 30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of GI bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect, increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of GI bleeding and ulceration.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding, and rarely, convulsions. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion. Monitor renal function.
Pregnancy & Lactation
Pregnancy: Category C in first and second trimesters; contraindicated in the third trimester due to risk of premature closure of fetal ductus arteriosus and renal dysfunction. Lactation: Naproxen is excreted in breast milk; use with caution or consider an alternative.
Side Effects
Contraindications
- Known hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma, urticaria, or allergic reactions)
- Active or history of recurrent peptic ulcer/hemorrhage
- Severe heart failure
- Severe renal impairment (CrCl < 30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of GI bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect, increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of GI bleeding and ulceration.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding, and rarely, convulsions. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion. Monitor renal function.
Pregnancy & Lactation
Pregnancy: Category C in first and second trimesters; contraindicated in the third trimester due to risk of premature closure of fetal ductus arteriosus and renal dysfunction. Lactation: Naproxen is excreted in breast milk; use with caution or consider an alternative.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Naproxen for various inflammatory and pain conditions. Ongoing research explores its long-term cardiovascular and gastrointestinal safety profiles and comparisons with other NSAIDs.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function (BUN, creatinine)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Assess cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest duration possible.
- Monitor renal function, blood pressure, and CBC periodically, especially in elderly or high-risk patients.
- Advise patients on signs of serious adverse events and when to seek immediate medical attention.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the prescribed dose.
- Avoid alcohol while taking this medicine.
- Report any signs of stomach bleeding (black stools, vomiting blood) immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Aponia may cause dizziness or drowsiness. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Limit alcohol intake.
- Maintain a balanced diet.
- Engage in regular, moderate exercise if appropriate for your condition.
- Avoid smoking, as it increases the risk of GI issues.
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