Apuldon
Generic Name
apuldon-10-mg-tablet
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apuldon 10 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Apuldon 10 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is typically prescribed for conditions like osteoarthritis, rheumatoid arthritis, and dysmenorrhea.
Uses & Indications
Dosage
Adults
Typically 10 mg, 2-3 times daily, or as directed by a physician. Maximum daily dose should not exceed 30 mg.
Elderly
Lower doses should be initiated in elderly patients, and dose escalation should be gradual with careful monitoring of renal function.
Renal_impairment
Dosage adjustment is required in patients with mild to moderate renal impairment; contraindicated in severe renal disease.
How to Take
Apuldon 10 mg Tablet should be taken orally, preferably with food or milk to minimize gastrointestinal discomfort. Do not crush or chew the tablet.
Mechanism of Action
Apuldon works by inhibiting cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By blocking their production, Apuldon reduces these symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Mainly excreted via the kidneys as metabolites, with a small portion excreted in feces.
Half life
2-4 hours
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver through oxidation and glucuronide conjugation pathways.
Side Effects
Contraindications
- Hypersensitivity to Apuldon or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Diuretics
May reduce the natriuretic effect of diuretics and increase the risk of renal toxicity.
Anticoagulants
Concomitant use with anticoagulants (e.g., warfarin) may increase the risk of bleeding.
ACE Inhibitors/ARBs
Can diminish the antihypertensive effect of ACE inhibitors and angiotensin receptor blockers (ARBs).
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Apuldon should be avoided during the third trimester of pregnancy due to potential risks to the fetus. Consult a doctor before use during early pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to Apuldon or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Diuretics
May reduce the natriuretic effect of diuretics and increase the risk of renal toxicity.
Anticoagulants
Concomitant use with anticoagulants (e.g., warfarin) may increase the risk of bleeding.
ACE Inhibitors/ARBs
Can diminish the antihypertensive effect of ACE inhibitors and angiotensin receptor blockers (ARBs).
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Apuldon should be avoided during the third trimester of pregnancy due to potential risks to the fetus. Consult a doctor before use during early pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by health authorities
Patent Status
Patent Expired
Clinical Trials
Apuldon has undergone various clinical trials to establish its efficacy and safety in indicated conditions, demonstrating significant pain relief and anti-inflammatory effects.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) for long-term use
- Liver function tests (e.g., ALT, AST) intermittently
- Complete Blood Count (CBC) for long-term therapy to monitor for anemia
Doctor Notes
- Emphasize taking with food to reduce GI adverse effects.
- Monitor renal function, especially in elderly or patients with pre-existing renal conditions, during prolonged therapy.
- Advise patients on the signs of GI bleeding and cardiovascular risks.
- Consider lowest effective dose for shortest duration.
Patient Guidelines
- Always take Apuldon with food or after a meal to reduce stomach upset.
- Do not exceed the prescribed dose without consulting your doctor.
- Inform your doctor if you experience any signs of gastrointestinal bleeding (e.g., black, tarry stools) or severe allergic reactions.
- Avoid consuming alcohol while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Apuldon may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid excessive alcohol intake as it may exacerbate GI side effects.
- Stay adequately hydrated, especially if you have renal concerns.
- Maintain a balanced diet and regular exercise as advised by your healthcare provider.
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Global Brand Names
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