Apuldon
Generic Name
Domperidone
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apuldon 5 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Apuldon 5 mg Suspension contains Domperidone, which is used to treat nausea and vomiting, and to improve gastric motility in conditions like dyspepsia.
Uses & Indications
Dosage
Adults
Typically 10 ml (10 mg) 3 times daily, 15-30 minutes before meals. Maximum 30 mg/day.
Elderly
Same as adults, but caution advised due to potential for increased cardiac risk.
Renal_impairment
Dosage reduction may be necessary. For severe impairment (CrCl <30 ml/min), frequency should be reduced to 1-2 times daily depending on severity.
How to Take
Shake the bottle well before use. Take orally, preferably 15-30 minutes before meals. Do not exceed the prescribed dose.
Mechanism of Action
Domperidone is a dopamine D2 and D3 receptor antagonist. It blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and in the stomach, thereby exhibiting antiemetic and prokinetic effects.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Approximately 66% excreted in feces, 33% in urine; largely as metabolites.
Half life
7-9 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 30-60 minutes.
Metabolism
Extensively metabolized in the liver by CYP3A4, N-dealkylation, and oxidative hydroxylation.
Side Effects
Contraindications
- Known hypersensitivity to Domperidone or any component
- Prolactin-releasing pituitary tumor
- Moderate to severe hepatic impairment
- Conditions where gastrointestinal stimulation is dangerous (e.g., GI hemorrhage, mechanical obstruction, perforation)
- Patients with known prolonged cardiac conduction intervals (e.g., QTc), significant electrolyte disturbances, or underlying cardiac diseases (e.g., congestive heart failure)
- Concomitant use with strong CYP3A4 inhibitors or QTc-prolonging drugs
Drug Interactions
Antacids and H2-receptor antagonists
Reduce bioavailability of Domperidone if taken concomitantly. Administer Domperidone before meals and antacids/H2 blockers after meals.
Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Increased plasma levels of Domperidone, leading to increased risk of QTc prolongation.
QTc prolonging drugs (e.g., certain antiarrhythmics, antipsychotics)
Additive effect on QTc interval, increasing risk of arrhythmias.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms may include drowsiness, disorientation, extrapyramidal reactions (e.g., dystonia, dyskinesia). Management is symptomatic and supportive, including gastric lavage and activated charcoal. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Domperidone is excreted in breast milk; advise caution, potential risk to infant.
Side Effects
Contraindications
- Known hypersensitivity to Domperidone or any component
- Prolactin-releasing pituitary tumor
- Moderate to severe hepatic impairment
- Conditions where gastrointestinal stimulation is dangerous (e.g., GI hemorrhage, mechanical obstruction, perforation)
- Patients with known prolonged cardiac conduction intervals (e.g., QTc), significant electrolyte disturbances, or underlying cardiac diseases (e.g., congestive heart failure)
- Concomitant use with strong CYP3A4 inhibitors or QTc-prolonging drugs
Drug Interactions
Antacids and H2-receptor antagonists
Reduce bioavailability of Domperidone if taken concomitantly. Administer Domperidone before meals and antacids/H2 blockers after meals.
Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Increased plasma levels of Domperidone, leading to increased risk of QTc prolongation.
QTc prolonging drugs (e.g., certain antiarrhythmics, antipsychotics)
Additive effect on QTc interval, increasing risk of arrhythmias.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms may include drowsiness, disorientation, extrapyramidal reactions (e.g., dystonia, dyskinesia). Management is symptomatic and supportive, including gastric lavage and activated charcoal. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Domperidone is excreted in breast milk; advise caution, potential risk to infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
Ongoing research continues to evaluate the safety and efficacy of Domperidone, particularly concerning its cardiac effects and alternative therapeutic uses.
Lab Monitoring
- ECG (especially in patients with pre-existing cardiac conditions or risk factors)
- Electrolyte levels (Potassium, Magnesium, Calcium)
- Liver function tests (LFTs)
Doctor Notes
- Emphasize ECG monitoring for high-risk patients.
- Counsel patients on potential cardiac symptoms.
- Review concomitant medications for drug interactions, especially QTc-prolonging agents.
Patient Guidelines
- Do not use for longer than 7 days without consulting a doctor.
- Report any cardiac symptoms (e.g., palpitations, fainting) immediately.
- Avoid self-medication for chronic conditions.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Patients should be advised not to drive or operate machinery if affected.
Lifestyle Advice
- Avoid alcohol consumption while on this medication.
- Maintain a healthy diet and fluid intake.
- If experiencing dyspepsia, try smaller, more frequent meals.
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Global Brand Names
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