Apuldon
Generic Name
Apuldine Hydrochloride
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apuldon 5 mg pediatric drop | ৳ 25.00 | N/A |
Description
Overview of the medicine
Apuldon 5 mg Pediatric Drop contains Apuldine Hydrochloride, a sedating antihistamine used for the symptomatic relief of allergic conditions and cold symptoms in infants and young children.
Uses & Indications
Dosage
Children_2_6_years
0.5 ml (2.5 mg) once daily or as directed by physician.
Infants_6_months_2_years
0.25 ml (1.25 mg) once daily or as directed by physician.
Renal_hepatic_impairment
Use with caution in renal or hepatic impairment; dose adjustment may be necessary.
How to Take
Administer orally using the calibrated dropper provided. May be given with or without food. Measure the dose accurately.
Mechanism of Action
Apuldine Hydrochloride acts as an H1-receptor antagonist, competitively inhibiting histamine at H1-receptors, thereby reducing allergic responses like sneezing, runny nose, and itching.
Pharmacokinetics
Onset
30 to 60 minutes
Excretion
Excreted primarily through urine as metabolites.
Half life
Approximately 6-12 hours
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Apuldine Hydrochloride or any component of the formulation
- Newborns and premature infants
- Breastfeeding mothers (due to sedative effects)
- Patients with severe respiratory depression
Drug Interactions
Anticholinergic drugs
Increased risk of anticholinergic side effects (e.g., dry mouth, urinary retention).
CNS Depressants (alcohol, sedatives, hypnotics)
May potentiate sedative effects.
Storage
Store below 30°C, away from direct sunlight and moisture. Keep upright. Do not freeze.
Overdose
Symptoms include severe drowsiness, coma, seizures, respiratory depression, cardiovascular collapse. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Category C in pregnancy. Not recommended during breastfeeding due to potential for sedation in infants.
Side Effects
Contraindications
- Hypersensitivity to Apuldine Hydrochloride or any component of the formulation
- Newborns and premature infants
- Breastfeeding mothers (due to sedative effects)
- Patients with severe respiratory depression
Drug Interactions
Anticholinergic drugs
Increased risk of anticholinergic side effects (e.g., dry mouth, urinary retention).
CNS Depressants (alcohol, sedatives, hypnotics)
May potentiate sedative effects.
Storage
Store below 30°C, away from direct sunlight and moisture. Keep upright. Do not freeze.
Overdose
Symptoms include severe drowsiness, coma, seizures, respiratory depression, cardiovascular collapse. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Category C in pregnancy. Not recommended during breastfeeding due to potential for sedation in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
Clinical Trials
Pre-clinical and clinical studies demonstrated efficacy and safety in pediatric populations for allergic symptoms.
Lab Monitoring
- No routine lab monitoring required.
Doctor Notes
- Advise parents on the importance of accurate dosing and potential for drowsiness.
- Evaluate underlying cause of allergy before prolonged use.
Patient Guidelines
- Do not exceed the recommended dose.
- Always use the provided dropper for accurate dosing.
- Keep out of reach of children.
- May cause drowsiness; avoid activities requiring mental alertness.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness and impair mental alertness. Caregivers should be cautious when performing tasks requiring full attention after administering to children.
Lifestyle Advice
- Ensure adequate hydration.
- Avoid other sedating substances if possible.
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Global Brand Names
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