Aripra
Generic Name
Aripiprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aripra 15 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Aripra 15 mg Tablet contains Aripiprazole, an atypical antipsychotic medication used to treat various mental health conditions such as schizophrenia, bipolar I disorder, and as an add-on treatment for major depressive disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 10-15 mg/day, target 15 mg/day once daily. Bipolar I Disorder: Initial 15 mg/day once daily. Major Depressive Disorder (adjunctive): Initial 2-5 mg/day, target 5-15 mg/day.
Elderly
Generally, lower initial doses are recommended, with careful titration based on individual response and tolerability.
Renal_impairment
No dosage adjustment is generally required for patients with renal impairment, but caution is advised.
How to Take
Aripra tablets should be taken orally, once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Aripiprazole is thought to exert its efficacy through a combination of partial agonism at dopamine D2 and serotonin 5-HT1A receptors and antagonism at serotonin 5-HT2A receptors. It also binds to α1-adrenergic and histamine H1 receptors.
Pharmacokinetics
Onset
Clinical effects may be observed within days, but full therapeutic effect may take several weeks.
Excretion
Mainly through feces (approximately 55%) and urine (approximately 25%).
Half life
Approximately 75 hours for aripiprazole and 94 hours for its active metabolite, dehydro-aripiprazole.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached within 3-5 hours.
Metabolism
Primarily hepatic, via CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- •Known hypersensitivity to aripiprazole or any component of the formulation.
Drug Interactions
CYP3A4 inducers (e.g., carbamazepine, rifampin)
May decrease aripiprazole levels; dose increase of aripiprazole may be needed.
CNS depressants (e.g., alcohol, benzodiazepines)
May potentiate CNS depressant effects; use with caution.
CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
May increase aripiprazole levels; dose reduction of aripiprazole may be needed.
CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine)
May increase aripiprazole levels; dose reduction of aripiprazole may be needed.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tremor, and tachycardia. Management is primarily supportive, including airway management, oxygenation, ventilation, and monitoring of cardiovascular function and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether aripiprazole is excreted in human milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, specific to batch.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Generic versions available
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Global Brand Names
International brand names for this medicine
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