Aripra
Generic Name
Aripiprazole
Manufacturer
Beximco Pharmaceuticals Ltd. (Example)
Country
Bangladesh (Example)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aripra 5 mg oral solution | ৳ 75.00 | N/A |
Description
Overview of the medicine
Aripiprazole is an atypical antipsychotic medication used to treat various mental health conditions, including schizophrenia, bipolar I disorder, and as an add-on treatment for major depressive disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 10-15 mg/day, target 10-30 mg/day. Bipolar I Disorder (Manic/Mixed): Initially 15 mg/day (monotherapy) or 10-15 mg/day (adjunctive), target 15-30 mg/day. Major Depressive Disorder (Adjunctive): Initially 2-5 mg/day, target 5-15 mg/day.
Elderly
Start with a lower dose and titrate slowly, monitoring for adverse effects.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Administer orally once daily, with or without food. Use the provided calibrated dosing device for accurate measurement of the oral solution.
Mechanism of Action
Aripiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors, modulating neurotransmitter activity in the brain to achieve its therapeutic effects.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to fully manifest.
Excretion
Excreted mainly through feces (55%) and urine (25%).
Half life
Approximately 75 hours for the parent drug and 94 hours for its active metabolite, dehydro-aripiprazole.
Absorption
Well-absorbed orally, reaching peak plasma concentrations within 3-5 hours.
Metabolism
Primarily metabolized in the liver by CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- •Known hypersensitivity to aripiprazole or any components of the formulation.
Drug Interactions
Antihypertensives
May potentiate orthostatic hypotension.
CYP3A4 Inhibitors (e.g., Ketoconazole)
Dose adjustment of aripiprazole may be necessary.
CYP3A4 Inducers (e.g., Carbamazepine, Rifampin)
Dose adjustment of aripiprazole may be necessary.
CNS Depressants (e.g., Alcohol, Benzodiazepines)
Increased risk of sedation.
CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine)
Dose adjustment of aripiprazole may be necessary.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, and potentially extrapyramidal symptoms. Treatment is primarily supportive, including maintaining an adequate airway, oxygenation, and ventilation, and managing symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Neonates exposed to antipsychotic drugs during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Aripiprazole is excreted in human milk; breastfeeding is generally not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24-36 months from the date of manufacture. Refer to the specific product packaging for exact shelf life.
Availability
Available in pharmacies and hospitals
Approval Status
FDA Approved
Patent Status
Patent Expired (generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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