Aristo-D3
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aristo d3 400 iu oral solution | ৳ 250.00 | N/A |
Description
Overview of the medicine
Aristo-D3 400 IU Oral Solution contains Cholecalciferol, which is Vitamin D3. It is essential for the regulation of calcium and phosphate homeostasis, bone health, and immune function. This oral solution is typically used for the prevention and treatment of vitamin D deficiency.
Uses & Indications
Dosage
Adults
For prevention of Vitamin D deficiency: 400-800 IU daily. For treatment of deficiency: Higher doses as prescribed by a physician, typically 800-2000 IU daily or higher depending on severity.
Elderly
Similar to adults. May require higher doses due to reduced skin synthesis and dietary intake.
Renal_impairment
Use with caution. Monitoring of calcium and phosphate levels is recommended. Active forms of Vitamin D may be preferred in severe renal impairment.
How to Take
The oral solution can be taken directly or mixed with a small amount of food or drink (e.g., milk, juice). It can be taken with or without food, but absorption may be enhanced when taken with a fatty meal. Take once daily as directed by your doctor or as per product instructions.
Mechanism of Action
Cholecalciferol (Vitamin D3) is metabolized in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form. Calcitriol acts on intestinal cells to increase calcium and phosphate absorption, on bone to promote mineralization, and on kidneys to regulate calcium and phosphate reabsorption.
Pharmacokinetics
Onset
Therapeutic effects typically observed within days to weeks, as metabolism to active form and physiological responses take time.
Excretion
Primarily excreted via bile into the feces. A small amount is excreted renally.
Half life
Cholecalciferol itself has a plasma half-life of approximately 19-25 hours. The main circulating metabolite, 25-hydroxyvitamin D, has a half-life of 2-3 weeks.
Absorption
Readily absorbed from the small intestine, primarily in the jejunum and ileum. Requires bile salts for optimal absorption. Absorbed into chylomicrons and transported via lymphatic system.
Metabolism
Initially hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component of the formulation
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (excessive vitamin D levels)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May counteract the effects of vitamin D.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate vitamin D metabolism, reducing its effects.
Cholestyramine, Colestipol, Orlistat
May decrease vitamin D absorption. Separate administration times.
Storage
Store below 30°C. Protect from light and moisture. Keep out of the reach and sight of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia, which can lead to nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, renal impairment, cardiac arrhythmias, and coma. Management involves discontinuing the medicine, a low calcium diet, increased fluid intake, and in severe cases, intravenous fluids and corticosteroids.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. This medicine can be used during pregnancy and breastfeeding at recommended daily allowances. However, high doses should be avoided as they may be teratogenic (cause birth defects). Consult a doctor for appropriate dosing.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component of the formulation
- Hypercalcemia (high calcium levels in blood)
- Hypervitaminosis D (excessive vitamin D levels)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May counteract the effects of vitamin D.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate vitamin D metabolism, reducing its effects.
Cholestyramine, Colestipol, Orlistat
May decrease vitamin D absorption. Separate administration times.
Storage
Store below 30°C. Protect from light and moisture. Keep out of the reach and sight of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia, which can lead to nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, renal impairment, cardiac arrhythmias, and coma. Management involves discontinuing the medicine, a low calcium diet, increased fluid intake, and in severe cases, intravenous fluids and corticosteroids.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. This medicine can be used during pregnancy and breastfeeding at recommended daily allowances. However, high doses should be avoided as they may be teratogenic (cause birth defects). Consult a doctor for appropriate dosing.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Check the expiry date on the packaging.
Availability
Pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Cholecalciferol (Vitamin D3) in treating and preventing vitamin D deficiency and related conditions like rickets, osteomalacia, and as an adjunct in osteoporosis management.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels (to assess vitamin D status)
- Serum calcium levels (to monitor for hypercalcemia)
- Serum phosphate levels
- Renal function (e.g., creatinine) for patients with renal impairment
Doctor Notes
- Advise patients on appropriate sun exposure and dietary sources of Vitamin D.
- Monitor serum 25(OH)D, calcium, and phosphate levels, especially in patients receiving high doses or with pre-existing renal conditions.
- Educate patients on symptoms of hypercalcemia and the importance of adhering to prescribed doses.
Patient Guidelines
- Take exactly as prescribed or directed. Do not exceed the recommended dose.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Maintain a balanced diet rich in calcium and get adequate sun exposure.
- Report any symptoms of hypercalcemia (e.g., nausea, vomiting, unusual tiredness) to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Aristo-D3 400 IU Oral Solution is not known to affect the ability to drive or operate machinery. If you experience any dizziness or vision changes, avoid driving or operating machinery.
Lifestyle Advice
- Regular sun exposure (safely and in moderation) can help the body produce its own Vitamin D.
- Include Vitamin D rich foods in your diet, such as fatty fish (salmon, mackerel), fortified milk, yogurt, and cereals.
- Regular weight-bearing exercise helps to maintain bone density.
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