Aronem
Generic Name
Meropenem
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aronem 1 gm injection | ৳ 1,350.00 | N/A |
| aronem 500 mg injection | ৳ 750.00 | N/A |
Description
Overview of the medicine
Meropenem is a carbapenem antibiotic used to treat a wide variety of bacterial infections, including intra-abdominal infections, meningitis, and pneumonia.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 g intravenously every 8 hours, depending on the severity and type of infection.
Elderly
Dosage adjustment may be required based on renal function.
Renal_impairment
Reduced dosage is necessary for patients with creatinine clearance ≤ 50 mL/min.
How to Take
Administered by intravenous infusion over 15-30 minutes or by intravenous bolus injection over 3-5 minutes.
Mechanism of Action
Meropenem is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Rapid
Excretion
Primarily excreted unchanged in the urine (approximately 70% as unchanged drug within 12 hours).
Half life
Approximately 1 hour in adults
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Limited hepatic metabolism, primarily hydrolyzed by dehydropeptidase-I (DHP-I) in the kidneys, but meropenem is resistant to DHP-I.
Side Effects
Contraindications
- •Hypersensitivity to meropenem or other carbapenems
- •History of severe hypersensitivity reactions to beta-lactam antibiotics (e.g., penicillin, cephalosporins)
Drug Interactions
Probenecid
Increases plasma concentration and prolongs the half-life of meropenem.
Valproic acid
May decrease valproic acid levels, leading to loss of seizure control.
Oral anticoagulants
Increased anticoagulant effect.
Storage
Store below 30°C. Protect from light. Reconstituted solution stability varies, refer to product information.
Overdose
In case of overdose, supportive treatment should be given. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in very low concentrations, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to product labeling.
Availability
Hospitals, Pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Generically available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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