Artica
Generic Name
Articoxib
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| artica 25 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Artica 25 mg Tablet contains Articoxib, a selective COX-2 inhibitor, used for the symptomatic treatment of osteoarthritis, rheumatoid arthritis, and for the relief of acute pain.
Uses & Indications
Dosage
Adults
Osteoarthritis: 25 mg once daily. Rheumatoid Arthritis: 25 mg once daily. Acute Pain/Dysmenorrhea: 25 mg once daily as needed, maximum 50 mg/day for short-term use.
Elderly
No dose adjustment is generally required, but caution is advised due to potential age-related decrease in renal function.
Renal_impairment
For mild to moderate impairment, no dose adjustment; for severe impairment, use with caution and consider dose reduction.
How to Take
Artica 25 mg Tablet should be swallowed whole with a glass of water, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Articoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins involved in inflammation, pain, and fever. Unlike non-selective NSAIDs, it spares COX-1, which is involved in gastric protection and platelet aggregation.
Pharmacokinetics
Onset
Pain relief typically begins within 30-60 minutes.
Excretion
Excreted predominantly in the urine (approx. 70%) and feces (approx. 30%) as metabolites.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (mainly CYP3A4 and CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to Articoxib or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure (NYHA Class II-IV)
- Severe renal impairment (creatinine clearance <30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma levels.
Methotrexate
May increase methotrexate toxicity.
SSRIs and SNRIs
Increased risk of gastrointestinal bleeding.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE inhibitors, Angiotensin II Receptor Blockers (ARBs), Diuretics
May reduce antihypertensive effect and increase risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic care; there is no specific antidote.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (premature closure of the ductus arteriosus). Use with caution during the first and second trimesters only if the potential benefit outweighs the risk. Articoxib is excreted in breast milk; therefore, use is not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to Articoxib or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure (NYHA Class II-IV)
- Severe renal impairment (creatinine clearance <30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma levels.
Methotrexate
May increase methotrexate toxicity.
SSRIs and SNRIs
Increased risk of gastrointestinal bleeding.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE inhibitors, Angiotensin II Receptor Blockers (ARBs), Diuretics
May reduce antihypertensive effect and increase risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic care; there is no specific antidote.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (premature closure of the ductus arteriosus). Use with caution during the first and second trimesters only if the potential benefit outweighs the risk. Articoxib is excreted in breast milk; therefore, use is not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by Regulatory Authorities
Patent Status
Under Patent
Clinical Trials
Articoxib has undergone extensive clinical trials demonstrating its efficacy and safety profile for its approved indications. Further post-marketing surveillance studies are ongoing.
Lab Monitoring
- Periodically monitor renal function (creatinine, BUN) in patients with pre-existing renal impairment or those on diuretics/ACE inhibitors.
- Monitor liver function tests (ALT, AST) periodically in patients with pre-existing hepatic impairment.
- Monitor blood pressure regularly.
Doctor Notes
- Consider the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Carefully assess cardiovascular and gastrointestinal risk factors before prescribing, especially for long-term use.
- Monitor blood pressure, renal function, and liver function during prolonged therapy.
Patient Guidelines
- Take Artica exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual symptoms, especially severe stomach pain, black stools, or swelling.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Artica may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet and engage in regular, moderate exercise appropriate for your condition.
- Avoid smoking and excessive alcohol consumption.
- Manage stress through relaxation techniques or hobbies.
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