Artica 25 mg Tablet should be swallowed whole with a glass of water, with or without food. It is recommended to take it at the same time each day.

Articoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins involved in inflammation, pain, and fever. Unlike non-selective NSAIDs, it spares COX-1, which is involved in gastric protection and platelet aggregation.

• •Hypersensitivity to Articoxib or any component of the tablet
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
• •Active peptic ulceration or gastrointestinal bleeding
• •Severe heart failure (NYHA Class II-IV)
• •Severe renal impairment (creatinine clearance <30 mL/min)
• •Severe hepatic impairment
• •Third trimester of pregnancy

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic care; there is no specific antidote.

Not recommended during the third trimester of pregnancy due to potential fetal harm (premature closure of the ductus arteriosus). Use with caution during the first and second trimesters only if the potential benefit outweighs the risk. Articoxib is excreted in breast milk; therefore, use is not recommended during lactation.