Asibalin
Generic Name
Pregabalin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asibalin 25 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Asibalin 25 mg Capsule contains Pregabalin, which is used to treat neuropathic pain, epilepsy, and generalized anxiety disorder. It works by reducing the abnormal electrical activity in the brain and by modifying the release of certain neurotransmitters.
Uses & Indications
Dosage
Adults
Typical starting dose is 75 mg twice daily or 50 mg three times daily, adjusted up to a maximum of 300 mg twice daily or 600 mg daily, depending on response and tolerability.
Elderly
Dosage may need to be reduced due to potential age-related decrease in renal function.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance; lower doses are recommended for patients with impaired renal function.
How to Take
Asibalin capsules should be taken orally, with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of several neurotransmitters, including glutamate, norepinephrine, and substance P, which are involved in pain signaling and seizure activity.
Pharmacokinetics
Onset
Within 1 week for neuropathic pain; varies by indication.
Excretion
Primarily excreted unchanged in the urine (approximately 98%).
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed following oral administration; peak plasma concentrations reached within 1.5 hours.
Metabolism
Negligible hepatic metabolism; less than 0.1% metabolized to N-methylated derivative.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May potentiate the sedative and respiratory depressant effects.
Thiazolidinedione antidiabetic agents (e.g., rosiglitazone, pioglitazone)
May cause weight gain and peripheral edema when co-administered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic; hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May potentiate the sedative and respiratory depressant effects.
Thiazolidinedione antidiabetic agents (e.g., rosiglitazone, pioglitazone)
May cause weight gain and peripheral edema when co-administered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic; hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture.
Availability
Available in pharmacies
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of pregabalin for its approved indications, including studies on neuropathic pain, fibromyalgia, and epilepsy. Ongoing research continues to explore its potential in other conditions.
Lab Monitoring
- No specific routine laboratory monitoring is typically required, but renal function should be assessed, especially in elderly patients or those with known renal impairment.
Doctor Notes
- Counsel patients on potential CNS depressant effects and the importance of gradual discontinuation.
- Monitor for signs of misuse, abuse, or dependence, especially in patients with a history of substance abuse.
- Assess renal function before initiating therapy and adjust dosage accordingly.
Patient Guidelines
- Do not stop taking Asibalin abruptly; gradually reduce the dose under medical supervision.
- Avoid alcohol while taking this medicine as it can increase side effects.
- Report any unusual mood changes or thoughts of self-harm to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Asibalin may cause dizziness, somnolence, and blurred vision. Patients should be advised not to drive or operate complex machinery until they are reasonably certain that Asibalin does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Be cautious when performing tasks requiring mental alertness, such as driving or operating machinery, until you know how Asibalin affects you.
- Maintain a balanced diet and regular exercise to manage potential weight gain.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Asibalin Brand
Other medicines available under the same brand name
