Asibalin
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asibalin 50 mg capsule | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Asibalin 50 mg Capsule contains Pregabalin, an anticonvulsant and neuropathic pain agent. It is used to treat neuropathic pain, fibromyalgia, partial onset seizures, and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose is typically 75 mg twice daily or 50 mg three times daily (150 mg/day). May be titrated up to 300-600 mg/day, usually in 2-3 divided doses, based on individual response and tolerability.
Elderly
Reduced doses may be required due to potential age-related decrease in renal function. Dosage should be adjusted based on creatinine clearance.
Renal_impairment
Dosage must be adjusted based on creatinine clearance. For CrCl 30-60 mL/min, initial 75 mg/day in 2-3 divided doses; max 300 mg/day. For CrCl 15-30 mL/min, initial 25-50 mg/day in 1-2 divided doses; max 150 mg/day. For CrCl <15 mL/min, initial 25 mg once daily or 50 mg every other day; max 75 mg/day.
How to Take
Asibalin capsules should be swallowed whole with water, with or without food. Do not chew, crush, or open the capsule. It should be taken at regularly spaced intervals.
Mechanism of Action
Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This leads to a decrease in neuronal excitability and pain transmission.
Pharmacokinetics
Onset
Within a few days for neuropathic pain relief; may take longer for full anxiolytic or anticonvulsant effects.
Excretion
Primarily renal excretion as unchanged drug; less than 0.1% excreted in feces.
Half life
Approximately 6.3 hours. Eliminated primarily by renal excretion.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1 hour. Bioavailability is ≥90% and is independent of dose.
Metabolism
Negligible metabolism in humans; approximately 98% of the dose is excreted unchanged in the urine.
Side Effects
Contraindications
- Hypersensitivity to Pregabalin or any component of the formulation.
- Severe allergic reactions to other GABA analogues.
Drug Interactions
ACE Inhibitors (e.g., lisinopril, enalapril)
May increase the risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
Concurrent use may enhance the depressant effects on the central nervous system, leading to increased sedation, dizziness, and respiratory depression.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and coma. Treatment is symptomatic and supportive. Hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human breast milk; therefore, breastfeeding is not recommended during treatment.
Side Effects
Contraindications
- Hypersensitivity to Pregabalin or any component of the formulation.
- Severe allergic reactions to other GABA analogues.
Drug Interactions
ACE Inhibitors (e.g., lisinopril, enalapril)
May increase the risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
Concurrent use may enhance the depressant effects on the central nervous system, leading to increased sedation, dizziness, and respiratory depression.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and coma. Treatment is symptomatic and supportive. Hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human breast milk; therefore, breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities in many countries
Patent Status
Patent expired for generic versions
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Pregabalin for its approved indications, including studies on neuropathic pain, fibromyalgia, and generalized anxiety disorder.
Lab Monitoring
- Monitor renal function regularly, especially in elderly patients or those with pre-existing renal impairment.
- Monitor for signs and symptoms of depression, suicidal thoughts, or unusual behavioral changes.
Doctor Notes
- Advise gradual tapering of the dose upon discontinuation to minimize withdrawal symptoms.
- Assess renal function before initiating treatment and adjust dose accordingly, especially in elderly patients.
- Monitor patients for signs of misuse or dependence due to its controlled substance status.
Patient Guidelines
- Take exactly as prescribed by your doctor and do not change the dose or stop the medicine without consulting your doctor.
- Do not stop taking Asibalin abruptly, as this may lead to withdrawal symptoms (e.g., anxiety, insomnia, nausea, sweating).
- Avoid alcohol while taking this medicine as it can increase side effects like dizziness and drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Asibalin may cause dizziness, somnolence, and blurred vision, which could impair your ability to drive or operate machinery. Avoid these activities until you are certain that the medicine does not adversely affect you.
Lifestyle Advice
- Be cautious when performing tasks that require mental alertness, such as driving or operating machinery, until you know how Asibalin affects you.
- Maintain a balanced diet and regular exercise, as weight gain can be a side effect.
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