Asibalin
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asibalin 75 mg capsule | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Asibalin 75 mg Capsule contains Pregabalin, an anticonvulsant and anxiolytic drug used to treat neuropathic pain, fibromyalgia, partial-onset seizures, and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose 75 mg twice daily or 50 mg three times daily (150 mg/day). May be increased to 150 mg twice daily or 100 mg three times daily (300 mg/day) within 1 week. Max dose 300 mg twice daily or 200 mg three times daily (600 mg/day).
Elderly
Dosage adjustments may be necessary due to potential age-related decrease in renal function. Start with a lower dose.
Renal_impairment
Dosage must be adjusted based on creatinine clearance. For CrCl 30-60 mL/min, 75 mg once or twice daily. For CrCl 15-30 mL/min, 25-50 mg once daily. For CrCl <15 mL/min, 25 mg once daily or every other day.
How to Take
Asibalin capsules should be swallowed whole with water, with or without food. Do not chew, crush, or open the capsule.
Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several excitatory neurotransmitters like glutamate, noradrenaline, and substance P. This results in reduced neuronal excitability, leading to its analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Pain relief can begin within 1 week for neuropathic pain. Anxiolytic effects may be seen earlier.
Excretion
Excreted almost entirely in the urine as unchanged drug. Renal elimination is the major route.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1 hour. Bioavailability is ≥ 90% and is independent of dose.
Metabolism
Minimally metabolized in humans (<2% of dose). Primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe kidney impairment without dose adjustment.
Drug Interactions
CNS depressants (e.g., alcohol, benzodiazepines, opioids)
Increased risk of sedation and respiratory depression.
Thiazolidinedione antidiabetics (e.g., pioglitazone, rosiglitazone)
May increase risk of weight gain and peripheral edema.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and coma. Treatment is supportive and symptomatic; hemodialysis may be beneficial in some cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, so caution is advised for breastfeeding mothers; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe kidney impairment without dose adjustment.
Drug Interactions
CNS depressants (e.g., alcohol, benzodiazepines, opioids)
Increased risk of sedation and respiratory depression.
Thiazolidinedione antidiabetics (e.g., pioglitazone, rosiglitazone)
May increase risk of weight gain and peripheral edema.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and coma. Treatment is supportive and symptomatic; hemodialysis may be beneficial in some cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, so caution is advised for breastfeeding mothers; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA (USA), DGDA (Bangladesh)
Patent Status
Off-patent (Original patent expired, generics available)
Clinical Trials
Extensive clinical trials have demonstrated pregabalin's efficacy and safety in neuropathic pain, fibromyalgia, partial seizures, and GAD. Ongoing research explores new indications and formulations.
Lab Monitoring
- Renal function (creatinine clearance) in patients with kidney impairment.
- Regular monitoring of weight due to potential weight gain and peripheral edema.
Doctor Notes
- Counsel patients on the importance of gradual tapering to avoid withdrawal.
- Monitor for signs of misuse or dependence, especially in patients with a history of substance abuse.
- Assess renal function before initiating and periodically during treatment.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Exercise caution until you know how Asibalin affects you.
Lifestyle Advice
- Maintain a healthy diet and exercise to manage potential weight gain.
- Avoid alcohol consumption while on this medication, as it can increase sedation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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