Asiclin
Generic Name
Clindamycin 300 mg Capsule
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asiclin 300 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Asiclin 300 mg Capsule contains Clindamycin, a lincosamide antibiotic used to treat a wide variety of bacterial infections, including those of the respiratory tract, skin and soft tissue, bones and joints, and gynecological infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
150-450 mg every 6-8 hours, depending on the severity of the infection. For severe infections, 300-450 mg every 6 hours.
Elderly
No specific dosage adjustment required based solely on age; adjust based on renal/hepatic function if impaired.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. For severe renal impairment (CrCl < 30 mL/min), dosage interval may need to be extended or dose reduced.
How to Take
Oral administration. Take capsules with a full glass of water, with or without food, to prevent esophageal irritation. Do not lie down for at least 30 minutes after taking the capsule.
Mechanism of Action
Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide bond formation and subsequent bacterial growth and replication.
Pharmacokinetics
Onset
Therapeutic effects usually observed within a few hours.
Excretion
Excreted through urine (10-20% as active drug) and feces (about 4% as active drug), with the remainder as metabolites.
Half life
Approximately 2-3 hours in adults, may be slightly longer in neonates and patients with severe renal or hepatic impairment.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract (approximately 90% bioavailability), with peak plasma concentrations occurring within 45-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver to active and inactive metabolites (e.g., N-demethyl clindamycin and clindamycin sulfoxide) by cytochrome P450 enzymes (CYP3A4 and CYP3A5).
Side Effects
Contraindications
- Hypersensitivity to Clindamycin or Lincomycin
- History of Clindamycin-associated colitis
- History of inflammatory bowel disease
Drug Interactions
Erythromycin
Antagonistic effects may occur, reducing clindamycin's efficacy.
Kaolin-pectin
May decrease the absorption of clindamycin if taken concurrently.
Neuromuscular blocking agents
May enhance the action of neuromuscular blocking agents, leading to increased or prolonged muscle paralysis.
Oral anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring close monitoring of INR.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, supportive and symptomatic treatment is recommended. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. In humans, clindamycin crosses the placenta. It is generally considered safe for use during pregnancy if clearly needed. Clindamycin is excreted in breast milk; therefore, caution should be exercised when administering to a nursing mother. Monitor breastfed infants for diarrhea, candidiasis, or allergic reactions.
Side Effects
Contraindications
- Hypersensitivity to Clindamycin or Lincomycin
- History of Clindamycin-associated colitis
- History of inflammatory bowel disease
Drug Interactions
Erythromycin
Antagonistic effects may occur, reducing clindamycin's efficacy.
Kaolin-pectin
May decrease the absorption of clindamycin if taken concurrently.
Neuromuscular blocking agents
May enhance the action of neuromuscular blocking agents, leading to increased or prolonged muscle paralysis.
Oral anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring close monitoring of INR.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, supportive and symptomatic treatment is recommended. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. In humans, clindamycin crosses the placenta. It is generally considered safe for use during pregnancy if clearly needed. Clindamycin is excreted in breast milk; therefore, caution should be exercised when administering to a nursing mother. Monitor breastfed infants for diarrhea, candidiasis, or allergic reactions.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of clindamycin for various bacterial infections. Ongoing research focuses on its role in emerging resistant strains and new formulations.
Lab Monitoring
- Periodic liver and kidney function tests for prolonged therapy
- Complete blood count (CBC) for prolonged therapy
- Stool examination for Clostridium difficile if diarrhea occurs
Doctor Notes
- Emphasize the importance of completing the full course.
- Advise patients to seek immediate medical attention if severe or persistent diarrhea develops.
- Caution against use in patients with a history of clindamycin-associated colitis.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the full course of treatment, even if you feel better, to prevent recurrence and resistance.
- Take with plenty of water to avoid throat irritation.
- Report any severe or persistent diarrhea to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Clindamycin is not known to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects.
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