Asizith
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asizith 250 mg tablet | ৳ 23.00 | ৳ 92.00 |
Description
Overview of the medicine
Azithromycin is a macrolide antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For most infections: 500 mg once daily for 3 days OR 500 mg on day 1, then 250 mg once daily for 4 days. For uncomplicated Chlamydial infections: 1 gram single oral dose.
Elderly
No dosage adjustment generally required for elderly patients.
Renal_impairment
No dosage adjustment necessary for mild-to-moderate renal impairment. Caution advised in severe renal impairment (CrCl < 10 mL/min).
How to Take
Oral, with or without food. Taking with food may reduce gastrointestinal upset.
Mechanism of Action
Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with the translation of mRNA.
Pharmacokinetics
Onset
Clinical improvement typically observed within 2-3 days of initiating treatment.
Excretion
Mainly excreted unchanged in the bile; a small amount is excreted in urine.
Half life
Long terminal elimination half-life of 2-4 days, allowing for once-daily dosing and shorter treatment courses.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Primarily metabolized in the liver by N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
May increase digoxin levels. Monitor digoxin levels.
Warfarin
May enhance the anticoagulant effect. Monitor INR closely.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for increased side effects.
Antacids (aluminum and magnesium-containing)
May decrease peak plasma concentrations of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management is symptomatic and supportive, as needed.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution in lactating mothers due to potential for adverse effects on breastfed infant.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
May increase digoxin levels. Monitor digoxin levels.
Warfarin
May enhance the anticoagulant effect. Monitor INR closely.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for increased side effects.
Antacids (aluminum and magnesium-containing)
May decrease peak plasma concentrations of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management is symptomatic and supportive, as needed.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution in lactating mothers due to potential for adverse effects on breastfed infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, hospitals, clinics worldwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of azithromycin for its approved indications across various patient populations.
Lab Monitoring
- Liver function tests (if hepatic impairment suspected or prolonged treatment)
- Renal function tests (if severe renal impairment)
Doctor Notes
- Counsel patients on the importance of completing the full course of therapy to prevent resistance and ensure eradication of infection.
- Be aware of potential drug interactions, especially with anticoagulants and drugs that prolong the QT interval.
- Consider liver function tests in patients with pre-existing hepatic impairment or during prolonged treatment.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Do not share this medication with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Azithromycin may cause dizziness or visual disturbances in some patients. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hydration during treatment.
- Avoid alcohol if experiencing gastrointestinal upset.
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