Asizith
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asizith 500 mg tablet | ৳ 35.00 | ৳ 140.00 |
Description
Overview of the medicine
Asizith 500 mg tablet contains Azithromycin, a macrolide antibiotic used to treat various bacterial infections of the respiratory tract, skin, ears, and sexually transmitted infections.
Uses & Indications
Dosage
Adults
For most infections: 500 mg once daily for 3 days OR 500 mg on day 1, then 250 mg once daily for 4 days. For Chlamydia: 1g single dose.
Elderly
No dosage adjustment needed unless severe renal or hepatic impairment.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment (CrCl >10 mL/min). Use with caution in severe impairment.
How to Take
Asizith 500 mg tablets can be taken with or without food. Swallow the tablet whole with water. Do not chew or crush.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with peptidyl translocation. This leads to inhibition of bacterial growth and replication.
Pharmacokinetics
Onset
Peak plasma concentrations reached in 2-3 hours.
Excretion
Mainly excreted unchanged in bile; some renal excretion.
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Primarily metabolized in the liver, but to a limited extent.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR.
Nelfinavir
Increased azithromycin serum concentrations.
QT prolonging drugs
Increased risk of QT prolongation and Torsades de Pointes.
Antacids (aluminum and magnesium containing)
Decreased peak serum levels of azithromycin; take azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive; gastric lavage and general supportive measures may be indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR.
Nelfinavir
Increased azithromycin serum concentrations.
QT prolonging drugs
Increased risk of QT prolongation and Torsades de Pointes.
Antacids (aluminum and magnesium containing)
Decreased peak serum levels of azithromycin; take azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive; gastric lavage and general supportive measures may be indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of azithromycin for its approved indications.
Lab Monitoring
- Liver function tests (LFTs) in patients with pre-existing hepatic impairment or prolonged therapy
- Renal function tests if severe renal impairment suspected
- INR if co-administered with warfarin
Doctor Notes
- Advise patients to report any signs of hypersensitivity or severe gastrointestinal issues immediately.
- Consider baseline ECG for patients at risk of QT prolongation before initiating therapy.
- Educate patients on the importance of completing the full course.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Asizith may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol consumption during treatment.
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