Atv
Generic Name
Atorvastatin
Manufacturer
XYZ Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| atv 10 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Atorvastatin is used to reduce high cholesterol and triglyceride levels, and to prevent cardiovascular events.
Uses & Indications
Dosage
Adults
Initial dose is 10-20 mg orally once daily. Dosage can be adjusted based on response up to a maximum of 80 mg once daily.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally once daily, with or without food, preferably at the same time each day. It can be taken in the morning or evening.
Mechanism of Action
Atorvastatin inhibits HMG-CoA reductase, an enzyme responsible for cholesterol synthesis in the liver, leading to reduced LDL-C levels.
Pharmacokinetics
Onset
Lipid-lowering effects observed within 2 weeks, maximal effect by 4 weeks.
Excretion
Excreted primarily via bile after hepatic metabolism.
Half life
Approximately 14 hours for the parent compound, with active metabolites contributing to a longer half-life of inhibitory activity (20-30 hours).
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily hepatic metabolism by cytochrome P450 3A4 (CYP3A4) to active and inactive ortho- and para-hydroxylated metabolites.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to atorvastatin or any component of the formulation
Drug Interactions
Digoxin
May increase digoxin concentrations; monitor digoxin levels.
Warfarin
May cause an increase in INR; monitor INR closely.
Cyclosporine, Gemfibrozil, Niacin (lipid-modifying doses)
Increased risk of myopathy/rhabdomyolysis and elevated atorvastatin levels.
Clarithromycin, Erythromycin, Itraconazole, Ketoconazole (CYP3A4 inhibitors)
Significantly increased atorvastatin plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific treatment for atorvastatin overdose. In case of overdose, symptomatic and supportive measures should be instituted. Monitor liver function tests and CK levels.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use adequate contraception.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to atorvastatin or any component of the formulation
Drug Interactions
Digoxin
May increase digoxin concentrations; monitor digoxin levels.
Warfarin
May cause an increase in INR; monitor INR closely.
Cyclosporine, Gemfibrozil, Niacin (lipid-modifying doses)
Increased risk of myopathy/rhabdomyolysis and elevated atorvastatin levels.
Clarithromycin, Erythromycin, Itraconazole, Ketoconazole (CYP3A4 inhibitors)
Significantly increased atorvastatin plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific treatment for atorvastatin overdose. In case of overdose, symptomatic and supportive measures should be instituted. Monitor liver function tests and CK levels.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use adequate contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities worldwide (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., ASCOT-LLA, MIRACL, TNT) have demonstrated atorvastatin's efficacy in reducing LDL-C and preventing cardiovascular events, including myocardial infarction and stroke.
Lab Monitoring
- Liver function tests (ALT, AST) should be performed before the initiation of treatment and periodically thereafter.
- Creatine kinase (CK) levels should be measured if muscle pain, tenderness, or weakness occurs.
Doctor Notes
- Emphasize the importance of adherence to diet and lifestyle modifications.
- Monitor liver function tests periodically, and creatine kinase if muscle symptoms develop.
- Counsel patients on potential drug interactions, especially with strong CYP3A4 inhibitors and grapefruit juice.
- Discontinue immediately if severe muscle symptoms or rhabdomyolysis is suspected.
Patient Guidelines
- Take Atv exactly as prescribed by your doctor.
- Do not stop taking Atv without consulting your doctor.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise.
- Follow a cholesterol-lowering diet and exercise regimen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose (within 12 hours), skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Atv generally does not impair the ability to drive or operate machinery. However, patients should be aware of potential side effects like dizziness that might affect their ability.
Lifestyle Advice
- Maintain a healthy diet low in saturated and trans fats, regular exercise, avoid smoking, and limit alcohol intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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