Medicine Information

Atorva

Name: Atorva
Brand: Atorva
Rating: 4.5 (117 reviews)

Tablet40 mgLipid-lowering agents (Statins)ATC: C10AA05

Generic Name

Atorvastatin Calcium

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
atv 40 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Atorvastatin is a lipid-lowering medication belonging to the statin class, used to reduce 'bad' cholesterol (LDL-C), triglycerides, and increase 'good' cholesterol (HDL-C) to prevent cardiovascular diseases.

Uses & Indications

Primary hypercholesterolemia and mixed dyslipidemia

Homozygous familial hypercholesterolemia

Prevention of cardiovascular events in patients at high risk

Dosage

Adults

Initial dose 10-20 mg once daily; maintenance dose typically 10-80 mg once daily. For 40 mg, it may be used as an initial dose in patients requiring a large reduction in LDL-C or as a maintenance dose.

Elderly

No dosage adjustment required.

Renal_impairment

No dosage adjustment required.

How to Take

Administer orally, once daily, with or without food, at any time of day.

Mechanism of Action

Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. This reduces cholesterol production in the liver, leading to an upregulation of LDL receptors and increased clearance of LDL from the blood.

Pharmacokinetics

Onset

Lipid-lowering effects observed within 2 weeks, maximal at 4 weeks.

Excretion

Primarily eliminated via biliary excretion following hepatic and/or extrahepatic metabolism; less than 2% of a dose is recovered in urine.

Half life

Parent drug plasma elimination half-life is approximately 14 hours; active metabolites contribute to a half-life of 20-30 hours.

Absorption

Rapidly absorbed; peak plasma concentration within 1-2 hours; absolute bioavailability approximately 14%.

Metabolism

Extensively metabolized in the liver by cytochrome P450 3A4 to active ortho- and parahydroxylated metabolites and inactive beta-oxidation products.

Side Effects

Contraindications

Active liver disease or unexplained persistent elevations of serum transaminases
Pregnancy
Lactation
Hypersensitivity to Atorvastatin or any component of the product

Drug Interactions

Niacin

Increased risk of myopathy/rhabdomyolysis, particularly with lipid-lowering doses of niacin (>1 g/day).

Colchicine

Reports of myopathy, including rhabdomyolysis, when coadministered with statins, including atorvastatin. Use with caution.

Gemfibrozil

Increased risk of myopathy/rhabdomyolysis; avoid co-administration if possible, or use with caution at lowest effective dose.

Cyclosporine

Concomitant use significantly increases atorvastatin plasma concentrations and risk of myopathy/rhabdomyolysis. Avoid high doses of atorvastatin.

Protease Inhibitors

May significantly increase atorvastatin plasma concentrations; specific dose limitations apply depending on the protease inhibitor (e.g., darunavir + ritonavir, lopinavir + ritonavir).

Itraconazole/Ketoconazole

Increase atorvastatin plasma concentrations; limit atorvastatin dose to 20 mg daily.

Clarithromycin/Erythromycin

Increase atorvastatin plasma concentrations; limit atorvastatin dose to 20 mg daily with clarithromycin, and caution with erythromycin.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

There is no specific treatment for Atorvastatin overdose. In the event of an overdose, symptomatic treatment and supportive measures should be instituted as required. Hemodialysis is not expected to significantly enhance atorvastatin clearance.

Pregnancy & Lactation

Atorvastatin is contraindicated during pregnancy and lactation due to the potential for fetal harm and excretion into breast milk. Women of childbearing potential should use adequate contraception.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets (Blister)30 Tablets (Blister)

Shelf Life

24 to 36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by FDA and DGDA

Patent Status

Patent expired, generics available

WHO Essential Medicine

Yes

Clinical Trials

Atorvastatin has been extensively studied in numerous large-scale clinical trials demonstrating its efficacy in reducing cardiovascular events in primary and secondary prevention, such as the ASCOT-LLA, TNT, and IDEAL studies.

Lab Monitoring

Liver function tests (ALT/AST) before initiation and periodically thereafter, or as clinically indicated.
Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) to monitor efficacy.

Doctor Notes

Monitor LFTs before and periodically during treatment.
Educate patients on symptoms of myopathy and rhabdomyolysis.
Consider dose adjustment in patients with severe renal impairment (though generally not needed).

Patient Guidelines

Take exactly as prescribed by your doctor.
Report any unexplained muscle pain, tenderness, or weakness immediately.
Continue following a cholesterol-lowering diet and exercise regimen.
Do not stop taking the medicine without consulting your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose.

Driving Precautions

Atorvastatin is generally not expected to affect the ability to drive or operate machinery. However, patients should be aware of possible side effects like dizziness.