Benprox
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benprox 250 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Benprox 250 mg Suspension is an oral antibiotic containing Cefixime, a third-generation cephalosporin. It is used to treat a wide range of bacterial infections in children, including respiratory tract infections, urinary tract infections, and ear infections.
Uses & Indications
Dosage
Adults
Not typically used in suspension form for adults. For children, dosage is based on body weight, usually 8 mg/kg/day once daily or 4 mg/kg every 12 hours. Maximum 400 mg/day.
Elderly
No specific dose adjustment is required for elderly patients unless there is severe renal impairment.
Renal_impairment
Dosage should be adjusted in patients with creatinine clearance < 60 mL/min. Consult physician for specific dose adjustments.
How to Take
Administer orally with or without food. Shake the bottle well before each use. Use the provided measuring spoon or cup to ensure accurate dosing. Complete the full course of treatment as prescribed by the physician.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby preventing the cross-linking of peptidoglycan chains which are essential for the strength and rigidity of the bacterial cell wall. This leads to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2 to 6 hours after a single oral dose.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Renal impairment significantly increases the half-life.
Half life
The plasma half-life is typically 3 to 4 hours.
Absorption
Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly alter the extent of absorption.
Metabolism
Cefixime is not significantly metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to penicillin (e.g., anaphylaxis).
Drug Interactions
Probenecid
May increase Cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported when co-administered with Cefixime.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and International Normalized Ratio (INR), leading to an increased risk of bleeding. Close monitoring is advised.
Storage
Store the unreconstituted powder below 30°C, protected from light and moisture. Store the reconstituted suspension in a refrigerator (2°C-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Cefixime should be used during pregnancy only if clearly needed. Small amounts are excreted in breast milk; caution should be exercised when administering to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to penicillin (e.g., anaphylaxis).
Drug Interactions
Probenecid
May increase Cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported when co-administered with Cefixime.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and International Normalized Ratio (INR), leading to an increased risk of bleeding. Close monitoring is advised.
Storage
Store the unreconstituted powder below 30°C, protected from light and moisture. Store the reconstituted suspension in a refrigerator (2°C-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Cefixime should be used during pregnancy only if clearly needed. Small amounts are excreted in breast milk; caution should be exercised when administering to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 24-36 months. Reconstituted suspension: 7-14 days when stored in a refrigerator (2°C-8°C).
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections in both pediatric and adult populations. Ongoing surveillance for antibiotic resistance and new clinical applications continues.
Lab Monitoring
- Periodic monitoring of renal function (creatinine, BUN) may be advisable during prolonged therapy, especially in patients with pre-existing renal impairment.
- Complete Blood Count (CBC) with differential for long-term use.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to patients/guardians.
- Advise on proper reconstitution and storage of the suspension.
- Be aware of potential drug interactions, especially with anticoagulants.
- Monitor for signs of C. difficile-associated diarrhea, especially in prolonged treatment.
Patient Guidelines
- Always complete the full course of treatment, even if symptoms improve, to prevent the development of antibiotic resistance.
- Shake the suspension well before each use to ensure the correct dose.
- Store the reconstituted suspension in the refrigerator and discard any unused portion after the recommended period (usually 7 or 14 days).
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Generally, Cefixime does not impair the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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