Benprox
Generic Name
Benprox 750 mg Tablet
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benprox 750 mg tablet | ৳ 18.00 | ৳ 108.00 |
Description
Overview of the medicine
Benprox 750 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever. It is effective in treating conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout.
Uses & Indications
Dosage
Adults
For musculoskeletal and joint disorders: 500 mg to 1000 mg daily, usually divided into two doses (e.g., 750 mg once daily or 250 mg-500 mg twice daily). Max dose 1250 mg/day for short periods. For acute gout: An initial dose of 750 mg, followed by 250 mg every 8 hours until the attack subsides.
Elderly
Use the lowest effective dose for the shortest possible duration. Start with a lower dose (e.g., 250 mg twice daily) and monitor for adverse effects.
Renal_impairment
Not recommended in patients with severe renal impairment (creatinine clearance < 30 mL/min). For moderate impairment, reduce the dose and monitor renal function closely.
How to Take
Take the tablet orally with a full glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet; swallow it whole.
Mechanism of Action
Benprox acts by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically both COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief typically begins within 1-2 hours.
Excretion
Mainly excreted in the urine (approximately 95%) as metabolites and conjugates, with a small amount excreted in the feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-4 hours after oral administration.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (CYP2C9), forming inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Benprox, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active or recurrent peptic ulceration/hemorrhage
- Severe heart failure
- Severe renal impairment (creatinine clearance < 30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
SSRIs and SNRIs
Increased risk of gastrointestinal bleeding.
ACE inhibitors and diuretics
Reduced antihypertensive and diuretic effects; increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive, including gastric emptying (emesis or lavage) and administration of activated charcoal. Hemodialysis is generally not beneficial.
Pregnancy & Lactation
Pregnancy: Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus and increased risk of maternal and fetal bleeding. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Lactation: Benprox is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Known hypersensitivity to Benprox, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active or recurrent peptic ulceration/hemorrhage
- Severe heart failure
- Severe renal impairment (creatinine clearance < 30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
SSRIs and SNRIs
Increased risk of gastrointestinal bleeding.
ACE inhibitors and diuretics
Reduced antihypertensive and diuretic effects; increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive, including gastric emptying (emesis or lavage) and administration of activated charcoal. Hemodialysis is generally not beneficial.
Pregnancy & Lactation
Pregnancy: Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus and increased risk of maternal and fetal bleeding. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Lactation: Benprox is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of NSAIDs like Benprox in various inflammatory and painful conditions, comparing them to placebos and other analgesics. Ongoing research focuses on minimizing side effects and identifying optimal dosing regimens.
Lab Monitoring
- Complete blood count (CBC) periodically, especially during long-term therapy
- Renal function tests (serum creatinine, BUN) periodically
- Liver function tests (ALT, AST) periodically
- Blood pressure monitoring
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing, especially for long-term use.
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Educate patients on symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Take Benprox with food or milk to reduce stomach upset.
- Do not exceed the prescribed dose or duration of treatment.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) or allergic reactions immediately.
- Avoid concomitant use of other NSAIDs or aspirin without consulting a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Benprox may cause dizziness or drowsiness. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid alcohol consumption while taking Benprox, as it can increase the risk of stomach bleeding.
- If you have a history of heart disease, discuss treatment options with your doctor.
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