Benprox
Generic Name
Naproxen
Manufacturer
Opsonin Pharma
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benprox 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Benprox 500 mg Tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions such as arthritis, muscle aches, and menstrual cramps.
Uses & Indications
Dosage
Adults
For pain and inflammation: 250-500 mg twice daily. Maximum daily dose is generally 1250 mg.
Elderly
Start with lower effective doses and monitor renal function. Generally 250 mg once or twice daily.
Renal_impairment
Use with caution. Dosage reduction may be necessary. Avoid in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually within 1 hour.
Excretion
Primarily excreted in the urine (approximately 95%) as naproxen, 6-O-desmethylnaproxen, and their conjugates.
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver by demethylation and conjugation to glucuronide.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium plasma concentrations, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
SSRIs (e.g., Fluoxetine)
Increased risk of GI bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, indigestion, nausea, vomiting. More severe cases can lead to gastrointestinal bleeding, convulsions, renal failure, or respiratory depression. Management is symptomatic and supportive; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in late pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during lactation; small amounts are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium plasma concentrations, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
SSRIs (e.g., Fluoxetine)
Increased risk of GI bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, indigestion, nausea, vomiting. More severe cases can lead to gastrointestinal bleeding, convulsions, renal failure, or respiratory depression. Management is symptomatic and supportive; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in late pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during lactation; small amounts are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety profile of Naproxen across its approved indications for pain and inflammation management.
Lab Monitoring
- Complete blood count (CBC) for anemia
- Renal function tests (BUN, creatinine, electrolytes) periodically
- Liver function tests (ALT, AST) periodically
- Blood pressure monitoring
Doctor Notes
- Counsel patients regarding potential gastrointestinal and cardiovascular risks associated with NSAID use.
- Consider co-administration of a proton pump inhibitor (PPI) for patients at high risk of GI complications.
- Periodically assess renal function, especially in elderly patients or those with pre-existing renal impairment or comorbidities.
- Titrate to the lowest effective dose for the shortest possible duration.
Patient Guidelines
- Do not exceed the recommended dose or duration of treatment.
- Always take this medicine with food or milk to reduce stomach upset.
- Avoid alcohol while taking this medicine as it may increase the risk of stomach bleeding.
- Inform your doctor about all other medications you are taking, especially blood thinners.
- Report any signs of stomach bleeding (e.g., black, tarry stools; vomiting blood) or allergic reactions (e.g., rash, swelling) immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how Benprox 500 mg Tablet affects you.
Lifestyle Advice
- Avoid smoking, which can worsen gastrointestinal risks associated with NSAIDs.
- Limit alcohol intake.
- Maintain a healthy and balanced diet.
- Engage in regular, moderate exercise as tolerated to help manage pain and inflammation.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Benprox Brand
Other medicines available under the same brand name
