Adults

Adults and children over 12 years: 400 mg once daily as a single dose or 200 mg every 12 hours. For Betasef 500 mg capsule, typically one 500 mg capsule once daily.

Elderly

No dosage adjustment is generally required for elderly patients unless they have severe renal impairment.

Renal_impairment

For creatinine clearance 21-60 mL/min, 300 mg daily. For creatinine clearance < 20 mL/min, 200 mg daily. For patients on chronic ambulatory peritoneal dialysis (CAPD) or hemodialysis, 200 mg daily.

Onset

Peak plasma concentrations are usually reached within 2-8 hours after oral administration.

Excretion

Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some is also excreted in the bile.

Half life

Plasma elimination half-life is typically 3-4 hours in healthy individuals, but can be prolonged in renal impairment.

Absorption

Approximately 40-50% absorbed orally. Absorption is not significantly altered by the presence of food.

Metabolism

Cefixime is not extensively metabolized in the body; about 10% may be metabolized.

Warfarin

May increase prothrombin time and INR, leading to increased bleeding risk. Close monitoring of coagulation parameters is recommended.

Probenecid

Increases cefixime plasma concentrations and prolongs its half-life by decreasing renal tubular secretion.

Carbamazepine

Concomitant use may lead to increased plasma levels of carbamazepine. Therapeutic drug monitoring may be necessary.