Bisopro
Generic Name
Bisoprolol Fumarate 1.25 mg Tablet
Manufacturer
Example Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bisopro 125 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Bisoprolol is a cardioselective beta-1 adrenergic blocking agent, primarily used for the management of hypertension, angina pectoris, and chronic stable heart failure. It works by slowing the heart rate and relaxing blood vessels.
Uses & Indications
Dosage
Adults
Hypertension/Angina: Initially 5 mg once daily, may be increased to 10 mg once daily. Max 20 mg/day. Heart Failure: Initially 1.25 mg once daily, doubled at 2-week intervals to max 10 mg once daily, as tolerated.
Elderly
No dosage adjustment is generally required unless there is significant renal or hepatic impairment. Start with the lowest effective dose.
Renal_impairment
For severe renal impairment (CrCl <20 mL/min), initial dose 2.5 mg once daily. Max 10 mg/day for hypertension/angina. For heart failure, use with caution and careful titration.
How to Take
Take orally, once daily in the morning with or without food. Swallow the tablet whole with water. Do not chew or crush.
Mechanism of Action
Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial contractility, and conduction velocity. This leads to a decrease in cardiac output and blood pressure. It also reduces renin release from the kidneys.
Pharmacokinetics
Onset
Within 2-4 hours, full effect within 2-6 weeks for hypertension.
Excretion
Approximately 50% excreted in urine as unchanged drug and 50% as metabolites. Renal and hepatic clearance are roughly equivalent.
Half life
Approximately 10-12 hours.
Absorption
Well absorbed (approx. 90%) from the gastrointestinal tract, with peak plasma concentrations reached within 2-4 hours.
Metabolism
About 50% metabolized in the liver to inactive metabolites by CYP2D6; remaining 50% excreted unchanged.
Side Effects
Contraindications
- •Acute heart failure or decompensated heart failure requiring intravenous inotropic therapy
- •Cardiogenic shock
- •Second or third degree AV block (without a pacemaker)
- •Sick sinus syndrome (without a pacemaker)
- •Severe bradycardia (<50 bpm)
- •Severe asthma or severe chronic obstructive pulmonary disease (COPD)
- •Severe peripheral arterial occlusive disease or Raynaud's syndrome
- •Metabolic acidosis
- •Pheochromocytoma (untreated)
Drug Interactions
Clonidine
Exacerbation of rebound hypertension upon clonidine withdrawal.
Insulin and oral antidiabetics
May mask symptoms of hypoglycemia (e.g., tachycardia).
Antiarrhythmics (e.g., amiodarone)
Increased risk of bradycardia and cardiac depression.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, AV block, and heart failure.
Other antihypertensives (e.g., ACE inhibitors, diuretics)
Potentiation of hypotensive effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include bradycardia, hypotension, bronchospasm, and acute cardiac insufficiency. Management involves symptomatic and supportive therapy, potentially including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Bisoprolol is excreted in breast milk; use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Widely available in pharmacies
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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