Take orally once daily, in the morning, with or without food. Swallow the tablet whole with some liquid, do not chew or crush.

Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, leading to a reduction in heart rate, cardiac output, and renin release from the kidneys, thereby lowering blood pressure. It also reduces myocardial oxygen demand, which helps in angina.

• •Acute heart failure or during episodes of decompensation of heart failure requiring intravenous inotropic therapy
• •Cardiogenic shock
• •Second or third degree AV block (without a pacemaker)
• •Sick sinus syndrome
• •Sinoatrial block
• •Severe bradycardia (< 60 beats/min before start of therapy)
• •Severe hypotension (systolic blood pressure < 100 mmHg)
• •Severe bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
• •Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
• •Untreated pheochromocytoma
• •Metabolic acidosis

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose include bradycardia, hypotension, bronchospasm, acute cardiac failure, and hypoglycemia. Management involves symptomatic and supportive treatment. In severe cases, intravenous atropine for bradycardia, glucagon for hypotension, and beta-sympathomimetics for bronchospasm may be necessary.

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Bisoprolol is excreted in human milk, so caution should be exercised when administered to a nursing mother.