C-3
Generic Name
C-3 200 mg Capsule
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| c 3 200 mg capsule | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
C-3 200 mg Capsule is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with various conditions.
Uses & Indications
Dosage
Adults
Osteoarthritis: 200 mg once daily or 100 mg twice daily. Rheumatoid Arthritis: 100-200 mg twice daily. Ankylosing Spondylitis: 200 mg once daily or 100 mg twice daily. Acute Pain/Primary Dysmenorrhea: 400 mg initially, followed by 200 mg if needed on the first day, then 200 mg twice daily.
Elderly
Generally, no dose adjustment is required in elderly patients, but caution is advised. Initiate at the lowest effective dose.
Renal_impairment
Severe renal impairment (CrCl <30 mL/min): Not recommended. Moderate impairment: Use with caution, consider reduced dose.
How to Take
C-3 capsules can be taken with or without food. To minimize potential gastrointestinal upset, it is generally recommended to take them with food.
Mechanism of Action
C-3 selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins involved in inflammation, pain, and fever. By inhibiting COX-2, it reduces these symptoms with a potentially lower risk of gastrointestinal side effects compared to non-selective NSAIDs.
Pharmacokinetics
Onset
Analgesic effects typically begin within 30-60 minutes.
Excretion
Excreted predominantly via urine (approx. 57%) and feces (approx. 27%) as metabolites; less than 3% excreted as unchanged drug.
Half life
Approximately 8-12 hours.
Absorption
Rapidly and well absorbed after oral administration, with peak plasma concentrations achieved within 2-3 hours. Food may increase absorption.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzyme CYP2C9 to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to C-3 or sulfonamides
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe renal or hepatic impairment
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Diuretics
May reduce natriuretic effect of loop and thiazide diuretics.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers
May reduce antihypertensive effect and increase risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be provided. There is no specific antidote. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C/D. Use of C-3 during the third trimester of pregnancy should be avoided due to the risk of premature closure of the fetal ductus arteriosus. Not recommended during breastfeeding due to potential excretion into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to C-3 or sulfonamides
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe renal or hepatic impairment
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Diuretics
May reduce natriuretic effect of loop and thiazide diuretics.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers
May reduce antihypertensive effect and increase risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be provided. There is no specific antidote. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C/D. Use of C-3 during the third trimester of pregnancy should be avoided due to the risk of premature closure of the fetal ductus arteriosus. Not recommended during breastfeeding due to potential excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Patent Protected
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of C-3 in the management of chronic pain and inflammatory conditions.
Lab Monitoring
- Monitor renal function (e.g., serum creatinine, BUN) periodically, especially in patients at risk of renal impairment.
- Monitor liver function tests (LFTs) in patients with pre-existing hepatic impairment or prolonged use.
- Monitor blood pressure regularly.
Doctor Notes
- Assess cardiovascular risk factors before initiating therapy and during treatment.
- Monitor for signs and symptoms of GI bleeding or ulceration, especially in elderly patients or those with a history of GI events.
- Consider the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any unusual bleeding, persistent stomach upset, or swelling to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
C-3 may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a balanced diet and regular light exercise.
- Avoid smoking and excessive alcohol consumption while on this medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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