Camlor
Generic Name
Candesartan Cilexetil
Manufacturer
Generic Pharmaceutical Company (e.g., Square Pharmaceuticals)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| camlor 8 mg tablet | ৳ 32.00 | ৳ 320.00 |
Description
Overview of the medicine
Candesartan Cilexetil 8 mg tablet is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, allowing blood to flow more easily and reducing the workload on the heart.
Uses & Indications
Dosage
Adults
For hypertension: Initial dose 8 mg once daily. May be increased to 16 mg once daily, and if necessary, further to 32 mg once daily. For heart failure: Initial dose 4 mg once daily. Dose may be doubled at intervals of at least 2 weeks to a maximum of 32 mg once daily.
Elderly
No initial dose adjustment is generally required for elderly patients.
Renal_impairment
For patients with mild to moderate renal impairment, no initial dose adjustment is necessary. For patients with severe renal impairment (creatinine clearance <30 mL/min/1.73 m²) or on hemodialysis, consider an initial dose of 4 mg once daily.
How to Take
Take Camlor 8 mg tablet orally, once daily, with or without food. Swallow the tablet whole with water. It is recommended to take it at the same time each day to maintain consistent levels in your body.
Mechanism of Action
Candesartan Cilexetil is a prodrug that is rapidly converted to the active drug candesartan during absorption. Candesartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues, including vascular smooth muscle and the adrenal gland. By blocking the AT1 receptor, candesartan inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased blood pressure, and reduced sodium and water retention.
Pharmacokinetics
Onset
Onset of antihypertensive effect within 2 hours; full effect within 4 weeks.
Excretion
Approximately 33% of candesartan is excreted in urine and 67% in feces via bile, primarily as unchanged drug. Renal clearance is about 0.19 L/h/kg.
Half life
Terminal elimination half-life of candesartan is approximately 9-15 hours.
Absorption
Candesartan cilexetil is well absorbed from the gastrointestinal tract and rapidly and completely hydrolyzed to candesartan during absorption. Absolute bioavailability is approximately 15%. Peak plasma concentrations of candesartan are reached 3-4 hours after tablet intake.
Metabolism
Candesartan is minimally metabolized in the liver (O-deethylation). It is not significantly metabolized by the cytochrome P450 system.
Side Effects
Contraindications
- Pregnancy and lactation.
- Severe hepatic impairment and/or cholestasis.
- Concomitant use with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Concomitant use in diabetic patients or patients with renal impairment (GFR <60 mL/min/1.73 m²) is contraindicated due to increased risk of hypotension, hyperkalemia, and renal function deterioration.
NSAIDs (Non-steroidal anti-inflammatory drugs)
May reduce the antihypertensive effect of candesartan and increase the risk of renal function deterioration, including possible acute renal failure, especially in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension (low blood pressure) and dizziness. Treatment is symptomatic and supportive, including close monitoring of vital signs and fluid/electrolyte balance. If ingestion is recent, gastric lavage may be considered.
Pregnancy & Lactation
Camlor is contraindicated during pregnancy due to the risk of fetal injury and death. If pregnancy is detected, discontinue Camlor immediately. It is not recommended during lactation as it is unknown whether candesartan is excreted in human milk.
Side Effects
Contraindications
- Pregnancy and lactation.
- Severe hepatic impairment and/or cholestasis.
- Concomitant use with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Concomitant use in diabetic patients or patients with renal impairment (GFR <60 mL/min/1.73 m²) is contraindicated due to increased risk of hypotension, hyperkalemia, and renal function deterioration.
NSAIDs (Non-steroidal anti-inflammatory drugs)
May reduce the antihypertensive effect of candesartan and increase the risk of renal function deterioration, including possible acute renal failure, especially in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension (low blood pressure) and dizziness. Treatment is symptomatic and supportive, including close monitoring of vital signs and fluid/electrolyte balance. If ingestion is recent, gastric lavage may be considered.
Pregnancy & Lactation
Camlor is contraindicated during pregnancy due to the risk of fetal injury and death. If pregnancy is detected, discontinue Camlor immediately. It is not recommended during lactation as it is unknown whether candesartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the manufacturer and specific formulation.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Candesartan has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of hypertension and heart failure, including studies like CHARM (Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity) program for heart failure.
Lab Monitoring
- Monitor blood pressure regularly.
- Monitor renal function (serum creatinine, GFR) periodically, especially in patients with pre-existing renal impairment.
- Monitor serum potassium levels, especially in patients receiving potassium-sparing diuretics or potassium supplements.
Doctor Notes
- Ensure regular monitoring of blood pressure, renal function (creatinine, GFR), and serum potassium, especially during dose titration and in high-risk patients.
- Caution in patients with bilateral renal artery stenosis, severe aortic/mitral stenosis, or hypertrophic obstructive cardiomyopathy due to risk of severe hypotension.
- Advise female patients of childbearing potential to use effective contraception. If pregnancy occurs, switch to an alternative antihypertensive regimen that is safer in pregnancy.
Patient Guidelines
- Take Camlor exactly as prescribed by your doctor.
- Do not stop taking the medication without consulting your doctor, even if you feel well.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any signs of swelling of the face, lips, tongue, or throat (angioedema) immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Camlor may cause dizziness or lightheadedness, especially when starting treatment or increasing the dose. If you experience these effects, avoid driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
- Monitor your blood pressure at home regularly and keep a record.
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