Capazi
Generic Name
Capazi-5-mg-tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| capazi 5 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Capazi 5 mg Tablet is used to treat high blood pressure (hypertension) and heart failure. It belongs to a class of medicines called Angiotensin II Receptor Blockers (ARBs). It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Hypertension: Initially 8 mg once daily, adjusted according to response; usual maintenance dose 8-32 mg once daily. For Capazi 5 mg, it may be used as a starting dose in some populations or for mild cases, however, typical starting doses for Candesartan are 8 mg. Heart failure: Initially 4 mg once daily, increasing at intervals of at least 2 weeks to 8 mg, 16 mg, then 32 mg once daily as tolerated.
Elderly
No initial dose adjustment is generally required in elderly patients.
Renal_impairment
In mild to moderate renal impairment, no initial dose adjustment is needed. For severe renal impairment or hemodialysis patients, a lower starting dose (e.g., 4 mg) may be considered, and careful monitoring is advised.
How to Take
Take Capazi 5 mg Tablet orally, once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Capazi (Candesartan Cilexetil) is an Angiotensin II Receptor Blocker (ARB). It selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to a reduction in blood pressure.
Pharmacokinetics
Onset
Blood pressure lowering effect starts within 2 hours; maximum reduction is achieved within 4-6 weeks.
Excretion
Excreted unchanged in urine (33%) and bile (67%).
Half life
Approximately 9 hours for candesartan.
Absorption
Candesartan cilexetil is an inactive prodrug that is rapidly and completely hydrolyzed to candesartan during absorption from the gastrointestinal tract. Absolute bioavailability of candesartan is approximately 15%. Peak plasma concentrations (Cmax) are reached within 3-4 hours.
Metabolism
Candesartan is not significantly metabolized by the cytochrome P450 system. It is primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to candesartan cilexetil or any component of the formulation.
- Pregnancy (second and third trimesters).
- Severe hepatic impairment and/or cholestasis.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Contraindicated in patients with diabetes or renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of ARBs and may worsen renal function, especially in elderly or volume-depleted patients. Monitor renal function.
Potassium-sparing diuretics, potassium supplements, or other agents that increase potassium levels
May lead to hyperkalemia. Monitor serum potassium levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension, dizziness, and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage may be considered. Administer activated charcoal. Candesartan is not removed by hemodialysis.
Pregnancy & Lactation
Capazi 5 mg Tablet is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal harm and death. Discontinue if pregnancy is detected. It is not recommended during lactation as it is unknown whether candesartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Candesartan cilexetil has been extensively studied in numerous clinical trials for its efficacy and safety in hypertension and heart failure, including landmark trials like CHARM (Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity).
Lab Monitoring
- Serum creatinine and blood urea nitrogen (BUN) periodically, especially in patients with renal impairment or heart failure.
- Serum potassium levels, especially in patients at risk of hyperkalemia (e.g., elderly, those on potassium-sparing diuretics or supplements).
Doctor Notes
- Emphasize the importance of consistent daily administration for optimal blood pressure control.
- Educate patients on symptoms of hypotension and hyperkalemia and advise them to report these promptly.
- Counsel female patients of childbearing potential about the risks during pregnancy and the need for effective contraception.
- Monitor renal function and serum potassium regularly, especially when initiating treatment or adjusting dosage, and in patients with comorbidities.
Patient Guidelines
- Take Capazi 5 mg Tablet exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual symptoms like severe dizziness, fainting, or swelling of the face, lips, or tongue immediately.
Missed Dose Advice
If you miss a dose of Capazi 5 mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Capazi 5 mg Tablet may cause dizziness or lightheadedness, especially when initiating treatment or increasing the dose. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
- Monitor your blood pressure regularly as instructed by your healthcare provider.
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