Cavazide
Generic Name
Irbesartan 150 mg and Hydrochlorothiazide 12.5 mg
Manufacturer
Sanofi
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cavazide 150 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Cavazide 150 mg Tablet is a combination medicine used to treat high blood pressure (hypertension). It contains an Angiotensin II Receptor Blocker (Irbesartan) and a thiazide diuretic (Hydrochlorothiazide) which work together to lower blood pressure effectively.
Uses & Indications
Dosage
Adults
Usually one tablet (Irbesartan 150 mg / Hydrochlorothiazide 12.5 mg) once daily. May be increased if blood pressure is not controlled.
Elderly
Initial dose adjustment not usually required, but monitor renal function.
Renal_impairment
Not recommended in severe renal impairment (CrCl < 30 mL/min). Dose adjustment may be necessary in moderate impairment.
How to Take
Oral, usually once daily with or without food.
Mechanism of Action
Irbesartan blocks AT1 receptors, reducing vasoconstriction and aldosterone secretion. Hydrochlorothiazide increases excretion of sodium and water by inhibiting sodium reabsorption in the distal convoluted tubule.
Pharmacokinetics
Onset
Irbesartan: ~1.5 hours. Hydrochlorothiazide: ~2 hours. Peak effect 6-12 hours.
Excretion
Irbesartan: Biliary and renal. Hydrochlorothiazide: Primarily renal.
Half life
Irbesartan: 11-15 hours. Hydrochlorothiazide: 5.6-14.8 hours.
Absorption
Irbesartan: Rapid, 60-80% bioavailability. Hydrochlorothiazide: Rapid, 60-80% bioavailability.
Metabolism
Irbesartan: Minor hepatic metabolism by CYP2C9. Hydrochlorothiazide: Not metabolized.
Side Effects
Contraindications
- Hypersensitivity to irbesartan, hydrochlorothiazide, or sulfonamide-derived drugs.
- Anuria.
- Pregnancy (second and third trimesters).
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
NSAIDs
May reduce antihypertensive effect and increase risk of renal impairment.
Lithium
Increased serum lithium levels and toxicity.
Aliskiren
Contraindicated in patients with diabetes or renal impairment.
Corticosteroids
May enhance potassium depletion (with hydrochlorothiazide component).
Potassium-sparing diuretics/potassium supplements
May increase serum potassium (with irbesartan component).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, dizziness, tachycardia, and electrolyte disturbances (e.g., hypokalemia, hyponatremia). Treatment is supportive and symptomatic; hemodialysis is not effective for irbesartan.
Pregnancy & Lactation
Contraindicated in the 2nd and 3rd trimesters of pregnancy due to fetal toxicity. Not recommended during lactation as both components are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to irbesartan, hydrochlorothiazide, or sulfonamide-derived drugs.
- Anuria.
- Pregnancy (second and third trimesters).
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
NSAIDs
May reduce antihypertensive effect and increase risk of renal impairment.
Lithium
Increased serum lithium levels and toxicity.
Aliskiren
Contraindicated in patients with diabetes or renal impairment.
Corticosteroids
May enhance potassium depletion (with hydrochlorothiazide component).
Potassium-sparing diuretics/potassium supplements
May increase serum potassium (with irbesartan component).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, dizziness, tachycardia, and electrolyte disturbances (e.g., hypokalemia, hyponatremia). Treatment is supportive and symptomatic; hemodialysis is not effective for irbesartan.
Pregnancy & Lactation
Contraindicated in the 2nd and 3rd trimesters of pregnancy due to fetal toxicity. Not recommended during lactation as both components are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Irbesartan/HCTZ in reducing blood pressure and improving cardiovascular outcomes in hypertensive patients.
Lab Monitoring
- Serum electrolytes (potassium, sodium)
- Renal function (creatinine, BUN)
- Blood pressure
- Liver function tests periodically
Doctor Notes
- Monitor renal function, serum electrolytes (especially potassium), and blood pressure regularly.
- Advise patients on lifestyle modifications for hypertension management.
- Caution in patients with severe renal impairment, hepatic impairment, or volume depletion.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking this medicine without consulting your doctor.
- Report any swelling of the face, lips, tongue, or throat immediately.
- Avoid potassium supplements or salt substitutes unless advised by your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness; avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Limit alcohol consumption.
- Quit smoking if applicable.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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