Ceclav
Generic Name
Cefaclor 125 mg and Clavulanic Acid 31.25 mg (as Potassium Clavulanate) Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceclav 125 mg suspension | ৳ 250.00 | N/A |
Description
Overview of the medicine
Ceclav-125 mg Suspension is an antibiotic medication combining Cefaclor, a second-generation cephalosporin, with Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat bacterial infections that are resistant to cefaclor alone due to beta-lactamase production. This suspension formulation is primarily used in children.
Uses & Indications
Dosage
Adults
Not typically prescribed for adults in this suspension strength; adults usually receive higher strength tablets (e.g., 250 mg or 500 mg every 8 hours).
Elderly
Not typically prescribed for elderly in this suspension strength. Dosage for elderly with normal renal function is similar to adult dosage forms.
Children
20 mg/kg/day in divided doses every 8-12 hours for mild to moderate infections; 40 mg/kg/day in divided doses for severe infections. Maximum 1g/day. For Ceclav-125 mg/5ml suspension, typical dose is 5ml (125mg cefaclor) two or three times daily for children, depending on age, weight and infection severity.
Renal_impairment
Initial dosage is similar. For severe renal impairment (creatinine clearance < 10 mL/min), dosage should be adjusted, and the total daily dose should be reduced.
How to Take
Shake the bottle well before each use. Administer orally with or without food. For best absorption and to minimize gastrointestinal upset, it is often recommended to take with food. Use the provided measuring device for accurate dosing.
Mechanism of Action
Cefaclor is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Clavulanic Acid is a beta-lactamase inhibitor that irreversibly binds to and inactivates beta-lactamase enzymes produced by bacteria, thereby protecting cefaclor from degradation and extending its spectrum of activity against beta-lactamase-producing strains.
Pharmacokinetics
Onset
Typically within 1 hour.
Excretion
Both are primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion. Approximately 60-85% of cefaclor and 30-45% of clavulanic acid are excreted unchanged in urine within 8 hours.
Half life
Cefaclor: approximately 0.6-1 hour; Clavulanic Acid: approximately 1 hour.
Absorption
Both cefaclor and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 0.5 to 1 hour for cefaclor and approximately 1 hour for clavulanic acid.
Metabolism
Cefaclor is minimally metabolized. Clavulanic acid undergoes extensive metabolism.
Side Effects
Contraindications
- •Hypersensitivity to cefaclor, other cephalosporins, or clavulanic acid.
- •History of severe hypersensitivity reaction to any beta-lactam antibiotic (e.g., penicillin, carbapenem).
- •Pseudomembranous colitis (history of).
Drug Interactions
Metformin
Potential for reduced metformin levels (less significant for cefaclor than other cephalosporins).
Probenecid
May increase and prolong cefaclor plasma levels by reducing renal tubular secretion.
Aminoglycosides
Potential for increased nephrotoxicity when co-administered, though rare for oral cefaclor.
Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, leading to increased bleeding risk. Monitor INR.
Storage
Store dry powder at room temperature, below 30°C (86°F), protected from moisture and light. Store reconstituted suspension in a refrigerator between 2-8°C (36-46°F). Do not freeze.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management is primarily supportive. Gastric lavage may be indicated if ingestion is recent. Hemodialysis may aid in the removal of cefaclor and clavulanic acid from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefaclor and clavulanic acid are excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years for the dry powder. Reconstituted suspension has a shorter shelf life, usually 7-14 days when stored in a refrigerator.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, DGDA)
Patent Status
Generic available (Patent expired for original formulation)
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Global Brand Names
International brand names for this medicine
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