Cefamax
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefamax 400 mg capsule | ৳ 120.00 | ৳ 480.00 |
Description
Overview of the medicine
Cefamax 400 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a variety of bacterial infections, including those of the respiratory tract, urinary tract, and ear.
Uses & Indications
Dosage
Adults
400 mg once daily or 200 mg every 12 hours, for 7 to 14 days, depending on the infection.
Elderly
No specific dose adjustment needed unless severe renal impairment.
Renal_impairment
For CrCl < 60 mL/min, dosage adjustment is necessary (e.g., 300 mg daily for CrCl 21-60 mL/min, 200 mg daily for CrCl < 20 mL/min).
How to Take
Cefamax 400 mg Capsule should be swallowed whole with a glass of water, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Cefixime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours.
Excretion
Primarily excreted by the kidneys (approximately 50% as unchanged drug in urine).
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food can delay absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized in the body.
Side Effects
Contraindications
- •Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation
- •History of serious hypersensitivity reactions to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR closely.
Nefazodone
May increase cefixime levels.
Carbamazepine
Elevated carbamazepine levels reported with concomitant use.
Oral Contraceptives
May reduce efficacy of oral contraceptives (use alternative contraception).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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