Adults

Not typically used for adults in this specific strength and formulation. Adult dosage usually 400 mg once daily.

Elderly

No specific dosage adjustment needed unless severe renal impairment (Creatinine Clearance < 60 mL/min).

Children

6 months to 12 years: 8 mg/kg/day once daily or in two divided doses. For Cefamax 90 mg Suspension, dose should be calculated based on body weight.

Renal_impairment

Dosage adjustment required for patients with Creatinine Clearance < 60 mL/min. For CrCl 21-60 mL/min or on peritoneal dialysis, dose reduction to 75% of standard. For CrCl < 20 mL/min or on hemodialysis, dose reduction to 50% of standard.

Onset

Within 1 hour of oral administration.

Excretion

Mainly renal excretion (50-60% unchanged in urine); some biliary excretion.

Half life

Approximately 3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent of absorption.

Metabolism

Limited metabolism; primarily excreted unchanged.

Nifedipine

May increase cefixime levels (though clinical significance is generally minor).

Carbamazepine

Rarely, increased carbamazepine levels have been reported with concurrent cefixime use.

Warfarin and other oral anticoagulants

Concurrent use may increase prothrombin time (INR), requiring close monitoring and possible anticoagulant dosage adjustment.