Ceficap
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceficap 100 mg suspension | ৳ 210.00 | N/A |
Description
Overview of the medicine
Ceficap 100 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Adults: Usually 200-400 mg once daily or 100-200 mg twice daily. (Suspension is primarily for pediatric use, adjust dose from higher strength forms if needed).
Children
Children (≥6 months): 8 mg/kg/day, given as a single daily dose or in two divided doses. For Ceficap 100 mg suspension, this typically means 5 ml (100 mg) once daily or 2.5 ml (50 mg) twice daily, depending on weight and severity.
Renal_impairment
Dosage adjustment is necessary in patients with severe renal impairment (creatinine clearance < 30 ml/min).
How to Take
Administer orally, with or without food. Shake the suspension bottle well before each use. Use the provided measuring cup or syringe for accurate dosing.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily via urine (approximately 50% unchanged drug) and bile.
Half life
3-4 hours
Absorption
Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly affect the extent of absorption.
Metabolism
Minimal hepatic metabolism; primarily eliminated as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe allergic reaction to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase the absorption of cefixime.
Carbamazepine
Elevated carbamazepine levels have been reported with co-administration of cefixime.
Warfarin and other anticoagulants
May increase prothrombin time (INR) and the risk of bleeding. Close monitoring of coagulation parameters is recommended.
Storage
Unreconstituted powder: Store below 30°C, protected from light and moisture. Reconstituted suspension: Store at room temperature (15-30°C) or in a refrigerator (2-8°C). Do not freeze. Discard any unused portion after the recommended period.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed. Cefixime is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe allergic reaction to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase the absorption of cefixime.
Carbamazepine
Elevated carbamazepine levels have been reported with co-administration of cefixime.
Warfarin and other anticoagulants
May increase prothrombin time (INR) and the risk of bleeding. Close monitoring of coagulation parameters is recommended.
Storage
Unreconstituted powder: Store below 30°C, protected from light and moisture. Reconstituted suspension: Store at room temperature (15-30°C) or in a refrigerator (2-8°C). Do not freeze. Discard any unused portion after the recommended period.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed. Cefixime is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: typically 2 years. Reconstituted suspension: 7-14 days (depending on storage conditions and manufacturer instructions).
Availability
Pharmacies, Hospitals
Approval Status
Approved by national regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various bacterial infections across different age groups, particularly in pediatric populations for suspensions.
Lab Monitoring
- Renal function should be monitored during prolonged therapy, especially in patients with pre-existing renal impairment.
- Complete blood count (CBC) may be monitored during prolonged therapy or if signs of blood dyscrasias appear.
- Liver function tests if clinically indicated.
Doctor Notes
- Emphasize to parents the importance of accurate measurement and completing the full course of therapy.
- Advise on reconstitution instructions and proper storage of the suspension.
- Monitor for signs of allergic reactions, pseudomembranous colitis, or severe dermatologic reactions.
- Consider renal function in elderly patients or those with pre-existing kidney disease for dose adjustment.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve, to prevent resistance and recurrence.
- Shake the suspension well before each dose to ensure uniform concentration.
- Use the provided measuring device for accurate dosing; do not use household spoons.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Ceficap 100 mg Suspension generally does not affect the ability to drive or operate machinery. However, if dizziness or drowsiness occurs, avoid such activities.
Lifestyle Advice
- Maintain good personal hygiene to help prevent the spread of infections.
- Ensure adequate fluid intake to stay hydrated.
- Avoid self-medication and only use antibiotics as prescribed by a healthcare professional.
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