Ceficap
Generic Name
Cefixime 400 mg capsule
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceficap 400 mg capsule | ৳ 55.00 | ৳ 220.00 |
Description
Overview of the medicine
Cefixime is a broad-spectrum, third-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
400 mg once daily or 200 mg every 12 hours. Duration depends on infection type, usually 7-14 days.
Elderly
No specific dose adjustment is required unless there is severe renal impairment.
Renal_impairment
For creatinine clearance 21-60 mL/min: 300 mg daily. For creatinine clearance <20 mL/min: 200 mg daily.
How to Take
Ceficap-400-mg-capsule can be taken orally with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Onset of antibacterial action typically within 1-2 hours.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine; a small portion is excreted via bile.
Half life
Plasma half-life is usually 3-4 hours, potentially longer in renal impairment.
Absorption
Approximately 40-50% orally absorbed. Peak plasma concentrations are reached 2-6 hours after administration.
Metabolism
Not extensively metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- Known hypersensitivity to penicillin antibiotics (due to potential cross-reactivity).
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding. Close monitoring is recommended.
Nifedipine
May increase cefixime absorption.
Probenecid
May increase cefixime plasma concentrations and prolong its half-life by decreasing renal excretion.
Carbamazepine
Concomitant use may increase carbamazepine plasma levels. Monitor carbamazepine levels.
Storage
Store at room temperature (below 30°C) in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed. Cefixime is excreted in human milk in small amounts; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- Known hypersensitivity to penicillin antibiotics (due to potential cross-reactivity).
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding. Close monitoring is recommended.
Nifedipine
May increase cefixime absorption.
Probenecid
May increase cefixime plasma concentrations and prolong its half-life by decreasing renal excretion.
Carbamazepine
Concomitant use may increase carbamazepine plasma levels. Monitor carbamazepine levels.
Storage
Store at room temperature (below 30°C) in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed. Cefixime is excreted in human milk in small amounts; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic available, off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections. Ongoing post-market surveillance continues to monitor its use.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
- INR/PT should be monitored closely in patients concurrently taking warfarin or other anticoagulants.
Doctor Notes
- Advise patients to complete the full course to prevent resistance.
- Caution in patients with a history of penicillin allergy due to potential cross-reactivity.
- Adjust dose in severe renal impairment. Monitor INR in patients on warfarin.
- Be aware of the risk of C. difficile-associated diarrhea.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Do not save medication for future infections or share it with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Ceficap may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they are sure the medicine does not adversely affect them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol if it causes gastrointestinal upset or exacerbates side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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