Ceficap
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceficap 200 mg capsule | ৳ 40.00 | ৳ 240.00 |
Description
Overview of the medicine
Ceficap-200 mg Capsule contains Cefixime, which is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
200-400 mg once daily or 200 mg twice daily, depending on the severity of infection. For uncomplicated gonorrhea, a single dose of 400 mg.
Elderly
No dosage adjustment needed based on age alone, but renal function should be assessed.
Renal_impairment
Dosage adjustment is recommended for patients with creatinine clearance less than 60 mL/min.
How to Take
Take orally with or without food. Complete the full course of treatment as prescribed by your doctor.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma levels reached within 2-6 hours.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours.
Half life
Plasma half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed, with peak plasma concentrations occurring 2-6 hours after administration.
Metabolism
Minimal hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase cefixime peak plasma levels and AUC.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without clinical bleeding. Monitor PT/INR carefully.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase cefixime peak plasma levels and AUC.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without clinical bleeding. Monitor PT/INR carefully.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA in Bangladesh)
Patent Status
Generic (Patent Expired)
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Post-marketing surveillance data also supports its profile.
Lab Monitoring
- Monitor renal function (creatinine clearance) in patients with severe renal impairment.
- Monitor prothrombin time (PT) / International Normalized Ratio (INR) in patients receiving concomitant anticoagulants.
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients and those with pre-existing renal impairment.
- Counsel patients on the importance of completing the full course of antibiotics to prevent resistance.
- Be vigilant for signs of Clostridium difficile-associated diarrhea, which can occur during or after antibiotic treatment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor, even if you start feeling better.
- Do not stop taking the medicine early, as this may lead to recurrent infection or antibiotic resistance.
- Do not share this medicine with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime usually does not affect the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Get adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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