Ceframed
Generic Name
Cefuroxime Axetil
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceframed 125 mg pediatric drop | ৳ 50.00 | N/A |
Description
Overview of the medicine
Cefuroxime axetil is a second-generation cephalosporin antibiotic used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this pediatric drop form; adult formulations vary.
Elderly
Not indicated for elderly in this pediatric drop form; adult formulations vary.
Renal_impairment
For children with severe renal impairment (creatinine clearance <30 ml/min), dosage adjustment may be required. Consult a physician.
How to Take
Administer orally. Shake the bottle well before each use. Can be taken with food to enhance absorption and minimize gastrointestinal upset. Use the provided measuring dropper for accurate dosing.
Mechanism of Action
It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved approximately 1-3 hours after administration with food.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 1-1.5 hours in healthy adults.
Absorption
Rapidly absorbed from the gastrointestinal tract and hydrolyzed to active cefuroxime in the intestinal mucosa and blood. Absorption is enhanced with food.
Metabolism
Cefuroxime is not significantly metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibiotic.
Drug Interactions
Probenecid
May increase cefuroxime plasma concentrations and prolong its half-life.
Oral Anticoagulants
May potentiate anticoagulant effect, requiring monitoring of INR.
Antacids/H2 Receptor Antagonists
May decrease the bioavailability of cefuroxime axetil.
Storage
Store the dry powder below 30°C, protect from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
Overdose may lead to neurological sequelae including convulsions. Management is supportive, including gastric lavage or induced emesis, and hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Cefuroxime is generally considered safe during pregnancy (Category B). Small amounts are excreted in breast milk; use with caution. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibiotic.
Drug Interactions
Probenecid
May increase cefuroxime plasma concentrations and prolong its half-life.
Oral Anticoagulants
May potentiate anticoagulant effect, requiring monitoring of INR.
Antacids/H2 Receptor Antagonists
May decrease the bioavailability of cefuroxime axetil.
Storage
Store the dry powder below 30°C, protect from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
Overdose may lead to neurological sequelae including convulsions. Management is supportive, including gastric lavage or induced emesis, and hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Cefuroxime is generally considered safe during pregnancy (Category B). Small amounts are excreted in breast milk; use with caution. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2-3 years. Reconstituted suspension: 7-10 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefuroxime axetil has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, particularly in pediatric populations.
Lab Monitoring
- Periodic monitoring of renal function may be necessary during prolonged therapy or in patients with pre-existing renal impairment.
- Complete blood count (CBC) if treatment is prolonged.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance and ensure complete eradication of infection.
- Advise parents/caregivers on proper reconstitution and administration techniques, including the use of the provided measuring device.
- Monitor for signs of hypersensitivity reactions and C. difficile-associated diarrhea.
Patient Guidelines
- Complete the entire course of medication as prescribed by the doctor, even if symptoms improve.
- Do not save medication for future use or share it with others.
- Shake the bottle well before each use to ensure proper mixing of the suspension.
- Store reconstituted suspension in the refrigerator and discard after 7 or 10 days (as per specific product leaflet).
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefuroxime axetil generally has no significant effect on the ability to drive or operate machinery. However, if dizziness occurs, caution should be exercised.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Ensure adequate fluid intake to avoid dehydration, especially if experiencing diarrhea.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Ceframed Brand
Other medicines available under the same brand name
