Ceframed
Generic Name
Cefixime
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceframed 250 mg capsule | ৳ 7.00 | N/A |
Description
Overview of the medicine
Ceframed 250 mg capsule contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
250 mg twice daily, or 500 mg once daily (two 250 mg capsules), depending on the infection. Duration typically 7-14 days.
Elderly
No specific dose adjustment generally needed unless severe renal impairment is present. Monitor renal function.
Renal_impairment
Dose adjustment required for creatinine clearance < 60 mL/min. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
Take orally with or without food. Swallow the capsule whole with a glass of water. It can be taken at the same time each day for best effect.
Mechanism of Action
Cefixime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations usually within 2-6 hours post-dose.
Excretion
Primarily excreted via urine (50-55% of absorbed dose) and bile/feces.
Half life
3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food can delay but not significantly alter absorption. Peak plasma concentrations reached within 2-6 hours.
Metabolism
Not significantly metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase cefixime Cmax and AUC, though clinical significance is usually minimal.
Carbamazepine
Cefixime may increase carbamazepine levels when co-administered. Monitor carbamazepine levels.
Oral Contraceptives
Potential for reduced efficacy of oral contraceptives (though controversial, advisable to use alternative contraception).
Warfarin and other anticoagulants
Concurrent use may increase prothrombin time (INR) and bleeding risk. Close monitoring is recommended.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not effective in removing cefixime. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Small amounts of cefixime are excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase cefixime Cmax and AUC, though clinical significance is usually minimal.
Carbamazepine
Cefixime may increase carbamazepine levels when co-administered. Monitor carbamazepine levels.
Oral Contraceptives
Potential for reduced efficacy of oral contraceptives (though controversial, advisable to use alternative contraception).
Warfarin and other anticoagulants
Concurrent use may increase prothrombin time (INR) and bleeding risk. Close monitoring is recommended.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not effective in removing cefixime. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Small amounts of cefixime are excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Complete blood count (CBC) during prolonged therapy.
- Renal function tests (blood urea nitrogen and serum creatinine), especially in patients with pre-existing renal impairment.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance.
- Counsel patients on potential gastrointestinal side effects, particularly diarrhea, and advise them to seek medical attention if severe or persistent.
- Be aware of potential drug interactions, especially with anticoagulants.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve, to prevent recurrence and resistance.
- Do not share this medication with others.
- Inform your doctor about any unusual or severe side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol consumption during antibiotic treatment as it may worsen side effects.
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