Ceframed
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceframed 125 mg suspension | ৳ 80.00 | N/A |
Description
Overview of the medicine
Ceframed 125 mg Suspension is an antibiotic medication containing Cefixime, a third-generation cephalosporin. It is primarily used to treat various bacterial infections in children, including those of the respiratory tract, urinary tract, and ear. It works by preventing the growth of bacteria.
Uses & Indications
Dosage
Adults
Not typically used for adults in 125 mg suspension form; adults usually take higher strength tablets (e.g., 200 mg or 400 mg).
Elderly
Dosage adjustment may be required in elderly patients with significant renal impairment, consulting a doctor.
Renal_impairment
Reduce dosage in patients with creatinine clearance < 30 mL/min; specific pediatric renal adjustment should be guided by a physician.
How to Take
Orally, with or without food. Shake the suspension well before each use. Use a measuring spoon or cup for accurate dosing. For children, the typical dose is 8 mg/kg/day, given as a single daily dose or in two divided doses for 5-10 days, depending on the infection severity and type.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bactericidal action.
Pharmacokinetics
Onset
Within hours of administration
Excretion
Primarily excreted unchanged in urine and bile.
Half life
Approximately 3-4 hours
Absorption
Approximately 40-50% orally absorbed, with peak plasma concentrations occurring 2-6 hours post-dose. Food may delay absorption but does not significantly affect the extent.
Metabolism
Minimal hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
May increase prothrombin time (INR), requiring close monitoring and dose adjustment.
Nifedipine
May increase peak plasma concentration and AUC of Cefixime.
Carbamazepine
Increased carbamazepine levels reported with concomitant use.
Oral anticoagulants
Enhanced anticoagulant effect.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 7-14 days (check specific product leaflet).
Overdose
Symptoms may include gastrointestinal distress (nausea, vomiting, diarrhea) and possibly neurological effects. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in very low concentrations into breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
May increase prothrombin time (INR), requiring close monitoring and dose adjustment.
Nifedipine
May increase peak plasma concentration and AUC of Cefixime.
Carbamazepine
Increased carbamazepine levels reported with concomitant use.
Oral anticoagulants
Enhanced anticoagulant effect.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 7-14 days (check specific product leaflet).
Overdose
Symptoms may include gastrointestinal distress (nausea, vomiting, diarrhea) and possibly neurological effects. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in very low concentrations into breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (unreconstituted); 7-14 days (reconstituted, refrigerated)
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various bacterial infections, particularly in pediatric populations. Numerous studies support its use for otitis media, pharyngitis, and UTIs.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (for prolonged therapy)
- Liver function tests (if signs of hepatic dysfunction)
Doctor Notes
- Confirm bacterial etiology before prescribing.
- Adjust dose for renal impairment.
- Advise parents on proper reconstitution and administration of suspension.
- Monitor for signs of *Clostridium difficile* diarrhea.
Patient Guidelines
- Complete the full course of antibiotic, even if symptoms improve.
- Do not save medication for future infections.
- Shake well before use and measure dose accurately.
- Store reconstituted suspension in refrigerator and discard after 7-14 days as per product leaflet.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or headache in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Drink plenty of fluids.
- Avoid alcohol during treatment (though not a direct interaction, general health advice).
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