Ceftax
Generic Name
Ceftriaxone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceftax 1 gm injection | ৳ 132.50 | N/A |
Description
Overview of the medicine
Ceftax 1 gm Injection is a broad-spectrum third-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typical dosage is 1-2 gm once daily by IV or IM route, depending on the severity of infection. Max 4 gm/day.
Elderly
No dose adjustment generally required unless severe renal or hepatic impairment is present.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment (CrCl <10 mL/min) and concomitant hepatic dysfunction.
How to Take
For intravenous (IV) use, reconstitute with sterile water for injection and infuse slowly over 30 minutes. For intramuscular (IM) use, reconstitute with lidocaine 1% solution and inject deeply into a large muscle.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Rapid; typically within 30 minutes for IV administration.
Excretion
About 50-60% via kidneys and 40-50% via biliary/fecal route, mostly as unchanged drug.
Half life
Approximately 6-9 hours (longer in neonates and patients with renal/hepatic impairment).
Absorption
Rapidly and completely absorbed after intramuscular (IM) administration, achieving peak plasma concentrations within 2-3 hours. Intravenous (IV) administration provides immediate peak levels.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to ceftriaxone, any cephalosporin, or penicillin
- Neonates with hyperbilirubinemia
- Neonates requiring IV calcium-containing solutions
Drug Interactions
Aminoglycosides
Enhanced antibacterial effect, but increased risk of nephrotoxicity (monitor renal function).
Calcium-containing solutions
Fatal precipitation in neonates; contraindicated.
Oral anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to vitamin K antagonism.
Storage
Store below 30°C, protected from light and moisture. Reconstituted solution should be used immediately or within 6 hours if stored at room temperature, or 24 hours if refrigerated.
Overdose
Management is primarily symptomatic and supportive. Ceftriaxone is not effectively removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; generally considered safe, but monitor infant for adverse effects like diarrhea or candidiasis.
Side Effects
Contraindications
- Known hypersensitivity to ceftriaxone, any cephalosporin, or penicillin
- Neonates with hyperbilirubinemia
- Neonates requiring IV calcium-containing solutions
Drug Interactions
Aminoglycosides
Enhanced antibacterial effect, but increased risk of nephrotoxicity (monitor renal function).
Calcium-containing solutions
Fatal precipitation in neonates; contraindicated.
Oral anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to vitamin K antagonism.
Storage
Store below 30°C, protected from light and moisture. Reconstituted solution should be used immediately or within 6 hours if stored at room temperature, or 24 hours if refrigerated.
Overdose
Management is primarily symptomatic and supportive. Ceftriaxone is not effectively removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; generally considered safe, but monitor infant for adverse effects like diarrhea or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored properly.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired (generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for its efficacy and safety in various bacterial infections.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver function tests (LFTs)
- Renal function tests (RFTs) for prolonged therapy or in patients with pre-existing impairment
Doctor Notes
- Always consider patient's allergy history to penicillins and cephalosporins.
- Monitor renal and hepatic function during prolonged therapy.
- Avoid concomitant use with calcium-containing IV solutions, especially in neonates.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Report any severe diarrhea or allergic reactions immediately.
- Do not use for viral infections (e.g., common cold).
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some patients; use caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Follow doctor's advice on diet and activity during illness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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