Cefuact
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
cefuact 125 mg suspension | ৳ 199.00 | N/A |
Description
Overview of the medicine
Cefuact 125 mg Suspension is an oral second-generation cephalosporin antibiotic containing cefuroxime axetil. It is used to treat a wide range of bacterial infections in children, including upper and lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media.
Uses & Indications
Dosage
Adults
Adults can take suspension, typically 125-250 mg twice daily depending on the infection. Not the primary form for adults.
Elderly
Similar to adults, but dosage adjustment may be needed based on renal function.
Children
Most infections (e.g., tonsillitis, pharyngitis, sinusitis): 125 mg twice daily or 15 mg/kg/day divided into two doses (max 250 mg/day). Otitis media or more severe infections: 250 mg twice daily or 30 mg/kg/day divided into two doses (max 500 mg/day).
Renal_impairment
Dosage should be adjusted in patients with significant renal impairment. Refer to specific guidelines.
How to Take
For oral administration. Shake the bottle well before each use. Can be taken with or without food, but taking it with food enhances absorption and may reduce gastrointestinal discomfort. Complete the full course of treatment as prescribed.
Mechanism of Action
Cefuroxime Axetil is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the cross-linking of peptidoglycan chains, which leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are usually reached within 2 to 3 hours after oral administration.
Excretion
Excreted unchanged primarily by glomerular filtration and tubular secretion in the urine. About 50% of the dose is excreted within 12 hours.
Half life
Approximately 1 to 1.5 hours in adults with normal renal function.
Absorption
Rapidly absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to cefuroxime. Absorption is enhanced when taken with food.
Metabolism
Cefuroxime itself is not significantly metabolized in the liver; it is hydrolyzed in the intestinal mucosa and blood to cefuroxime.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration of probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime and peak serum concentration.
Oral Anticoagulants (e.g., Warfarin)
Cefuroxime may alter gut flora, leading to lower vitamin K synthesis and potentiation of anticoagulant effect.
Antacids/H2-receptor antagonists/PPIs
Drugs that reduce gastric acidity may decrease the bioavailability of cefuroxime axetil, potentially reducing its effectiveness.
Storage
Store the dry powder below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-10 days. Do not freeze.
Overdose
Overdose of cefuroxime can lead to neurological sequelae including convulsions. Management should be symptomatic and supportive. Hemodialysis and peritoneal dialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefuroxime is excreted into breast milk in small amounts; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration of probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime and peak serum concentration.
Oral Anticoagulants (e.g., Warfarin)
Cefuroxime may alter gut flora, leading to lower vitamin K synthesis and potentiation of anticoagulant effect.
Antacids/H2-receptor antagonists/PPIs
Drugs that reduce gastric acidity may decrease the bioavailability of cefuroxime axetil, potentially reducing its effectiveness.
Storage
Store the dry powder below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-10 days. Do not freeze.
Overdose
Overdose of cefuroxime can lead to neurological sequelae including convulsions. Management should be symptomatic and supportive. Hemodialysis and peritoneal dialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefuroxime is excreted into breast milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: Typically 2 years from manufacturing date. Reconstituted suspension: 7-10 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved (Generic)
Patent Status
Patent expired for generic
WHO Essential Medicine
YesClinical Trials
Cefuroxime Axetil has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different age groups, particularly in pediatric populations for formulations like suspension.
Lab Monitoring
- Renal function tests (for patients with impaired renal function or on prolonged therapy)
- Complete Blood Count (CBC) for prolonged treatment
- Liver function tests (if abnormalities observed or suspected)
Doctor Notes
- Emphasize the importance of completing the full prescribed course of antibiotics, even if symptoms improve.
- Advise parents on proper reconstitution, storage, and accurate dosing using the provided measuring device.
- Be vigilant for signs of allergic reactions (rash, difficulty breathing) or *Clostridium difficile* infection (severe, persistent diarrhea).
- Educate patients/caregivers on potential drug interactions and food interactions, especially regarding enhanced absorption with food.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Shake the suspension well before each use.
- Use the provided measuring device for accurate dosing.
- Do not share your medication with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness. Patients should be cautious when driving or operating machinery until they know how Cefuact affects them.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Drink adequate fluids to stay hydrated, especially if experiencing diarrhea.
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