Cefuact
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefuact 250 mg tablet | ৳ 25.00 | N/A |
Description
Overview of the medicine
Cefuroxime Axetil is a broad-spectrum, second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, skin and soft tissues.
Uses & Indications
Dosage
Adults
Most infections: 250 mg twice daily. More severe infections or bronchitis/pneumonia: 500 mg twice daily. Uncomplicated gonorrhea: 1000 mg as a single dose.
Elderly
No specific dose adjustment needed based solely on age, but consider renal function.
Renal_impairment
For creatinine clearance < 30 mL/min, dosage adjustment is required. Consult prescribing information for specific recommendations.
How to Take
Take Cefuact 250 mg Tablet orally with food to optimize absorption and reduce potential gastrointestinal upset. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
Cefuroxime Axetil acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Approximately 1 hour for peak plasma concentrations.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
1 to 1.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract and hydrolyzed to active cefuroxime. Absorption is enhanced when taken with food.
Metabolism
Not significantly metabolized in the liver; largely excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or to any of the excipients.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).
Drug Interactions
Warfarin
Concomitant use with oral anticoagulants may cause an increase in INR. Careful monitoring is advised.
Probenecid
Concomitant administration with probenecid increases the area under the plasma concentration-time curve of cefuroxime and prolongs its duration of action.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Advise additional barrier contraception.
Antacids/H2 Blockers
Drugs that reduce gastric acidity can lead to a lower bioavailability of Cefuroxime Axetil. Administer Cefuroxime Axetil at least 2 hours before or after antacids or H2 blockers.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include cerebral irritation leading to convulsions. Management is primarily supportive; hemodialysis or peritoneal dialysis may be considered to remove cefuroxime from the body, especially in cases of severe renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution is advised when administering to a nursing mother. Monitor breastfed infants for potential adverse effects like diarrhea or thrush.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or to any of the excipients.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).
Drug Interactions
Warfarin
Concomitant use with oral anticoagulants may cause an increase in INR. Careful monitoring is advised.
Probenecid
Concomitant administration with probenecid increases the area under the plasma concentration-time curve of cefuroxime and prolongs its duration of action.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Advise additional barrier contraception.
Antacids/H2 Blockers
Drugs that reduce gastric acidity can lead to a lower bioavailability of Cefuroxime Axetil. Administer Cefuroxime Axetil at least 2 hours before or after antacids or H2 blockers.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include cerebral irritation leading to convulsions. Management is primarily supportive; hemodialysis or peritoneal dialysis may be considered to remove cefuroxime from the body, especially in cases of severe renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution is advised when administering to a nursing mother. Monitor breastfed infants for potential adverse effects like diarrhea or thrush.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies and Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefuroxime Axetil has undergone extensive clinical trials demonstrating its efficacy and safety in treating a variety of bacterial infections across different patient populations, forming the basis for its widespread approval and use.
Lab Monitoring
- Periodic monitoring of renal function (creatinine, BUN) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Complete Blood Count (CBC) and Liver Function Tests (LFTs) may be considered for patients on long-term therapy.
Doctor Notes
- Emphasize the importance of completing the full antibiotic course to patients.
- Counsel patients on potential gastrointestinal side effects and the benefit of taking with food.
- Be alert for signs of severe allergic reactions (anaphylaxis) or C. difficile-associated diarrhea, especially with prolonged use.
- Adjust dosage for patients with significant renal impairment.
Patient Guidelines
- Complete the entire prescribed course of Cefuact, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Take the tablet with food to enhance absorption and minimize stomach upset.
- Do not share your medication with others, as it may not be suitable for their condition.
- Inform your doctor about any unusual or severe side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefuact 250 mg Tablet may cause dizziness, which could affect your ability to drive or operate machinery. If you experience dizziness, avoid these activities.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Ensure adequate fluid intake to stay hydrated, especially if experiencing diarrhea.
- Avoid alcohol during treatment, as it may worsen gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Cefuact Brand
Other medicines available under the same brand name
