Cefuact
Generic Name
Cefuroxime Axetil 500 mg Tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefuact 500 mg tablet | ৳ 45.00 | N/A |
Description
Overview of the medicine
Cefuact 500 mg Tablet is an antibiotic used to treat a wide variety of bacterial infections, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and otitis media.
Uses & Indications
Dosage
Adults
Typically 250 mg to 500 mg twice daily depending on the infection.
Elderly
Similar to adult dosage, but consider renal function.
Renal_impairment
Dosage adjustment required for severe renal impairment.
How to Take
Take orally, preferably with food, to enhance absorption.
Mechanism of Action
Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.
Pharmacokinetics
Onset
Within approximately 1 hour.
Excretion
Mainly excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 1-1.5 hours.
Absorption
Well absorbed from the gastrointestinal tract after oral administration, especially when taken with food.
Metabolism
Not extensively metabolized in the liver; largely hydrolyzed to cefuroxime.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or penicillins.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent.
Drug Interactions
Probenecid
Increases cefuroxime plasma concentrations and prolongs its half-life.
Oral contraceptives
May reduce the efficacy of oral contraceptives; additional contraceptive measures may be needed.
Aminoglycosides/Loop diuretics
Concurrent use with high doses may increase nephrotoxicity (though less common with cefuroxime).
Antacids/H2-receptor antagonists
May decrease the bioavailability of cefuroxime axetil, especially when taken shortly before or after.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include cerebral irritation leading to convulsions. Management is supportive; hemodialysis may be effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or penicillins.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent.
Drug Interactions
Probenecid
Increases cefuroxime plasma concentrations and prolongs its half-life.
Oral contraceptives
May reduce the efficacy of oral contraceptives; additional contraceptive measures may be needed.
Aminoglycosides/Loop diuretics
Concurrent use with high doses may increase nephrotoxicity (though less common with cefuroxime).
Antacids/H2-receptor antagonists
May decrease the bioavailability of cefuroxime axetil, especially when taken shortly before or after.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include cerebral irritation leading to convulsions. Management is supportive; hemodialysis may be effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of cefuroxime axetil for its approved indications.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Liver function tests
- Complete blood count (for prolonged therapy)
Doctor Notes
- Assess patient's history of hypersensitivity to beta-lactam antibiotics.
- Adjust dosage in patients with renal impairment.
- Advise patients to complete the full course of therapy.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if you feel better.
- Take with food to improve absorption and reduce gastrointestinal upset.
- Do not take antacids within 2 hours of taking Cefuact.
- Inform your doctor about any allergic reactions or ongoing medications.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness; exercise caution when driving or operating machinery.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Get adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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