Cefurim
Generic Name
Cefuroxime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cefurim 250 mg tablet | ৳ 25.10 | ৳ 100.40 |
Description
Overview of the medicine
Cefurim 250 mg tablet contains Cefuroxime axetil, a broad-spectrum second-generation cephalosporin antibiotic. It is effective against a wide range of gram-positive and gram-negative bacteria and is used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Most infections: 250 mg twice daily. Severe infections or bronchitis: 500 mg twice daily. Uncomplicated UTIs: 125-250 mg twice daily. Uncomplicated gonorrhea: 1000 mg as a single dose.
Elderly
Similar to adult dosage; dose adjustment may be required in patients with significantly impaired renal function.
Renal_impairment
Creatinine clearance 10-29 mL/min: 250 mg once daily. Creatinine clearance <10 mL/min or on hemodialysis: 250 mg every 48 hours or after dialysis.
How to Take
Take orally with food to optimize absorption and reduce gastrointestinal upset.
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bactericidal activity and cell lysis.
Pharmacokinetics
Onset
Peak plasma concentrations achieved in approximately 2-3 hours after oral administration.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 1.2 to 1.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to active cefuroxime. Food enhances absorption.
Metabolism
Cefuroxime itself is not metabolized; the axetil ester is hydrolyzed to cefuroxime.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or to any component of the formulation.
- History of severe hypersensitivity reaction to any beta-lactam antibiotic (e.g., penicillin, carbapenems).
Drug Interactions
Warfarin
May enhance anticoagulant effect; monitor INR.
Probenecid
Increases and prolongs cefuroxime serum concentrations.
Oral Contraceptives
May reduce efficacy of estrogen-containing oral contraceptives; advise use of alternative birth control.
Antacids/H2 blockers/PPIs
May reduce bioavailability; administer cefuroxime at least 2 hours before or after these agents.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose can lead to neurological sequelae including seizures. Management involves supportive care and symptomatic treatment. Hemodialysis can remove cefuroxime from the blood.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or to any component of the formulation.
- History of severe hypersensitivity reaction to any beta-lactam antibiotic (e.g., penicillin, carbapenems).
Drug Interactions
Warfarin
May enhance anticoagulant effect; monitor INR.
Probenecid
Increases and prolongs cefuroxime serum concentrations.
Oral Contraceptives
May reduce efficacy of estrogen-containing oral contraceptives; advise use of alternative birth control.
Antacids/H2 blockers/PPIs
May reduce bioavailability; administer cefuroxime at least 2 hours before or after these agents.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose can lead to neurological sequelae including seizures. Management involves supportive care and symptomatic treatment. Hemodialysis can remove cefuroxime from the blood.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefuroxime has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Specific trials for 'Cefurim' brand are not publicly detailed but rely on the generic compound's established profile.
Lab Monitoring
- Monitor renal function periodically in patients with impaired renal function or during prolonged high-dose therapy.
- Liver function tests may be monitored if abnormalities are suspected.
Doctor Notes
- Before initiating therapy, inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.
- Determine bacterial susceptibility prior to and during therapy when appropriate.
- Adjust dosage in patients with renal impairment.
- Advise patients to take with food.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if you feel better.
- Take with food to improve absorption and reduce stomach upset.
- Do not share your medicine with others.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefuroxime may cause dizziness. Patients should be cautioned about driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Get adequate rest to aid recovery.
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