Take orally with or without food. Swallow the tablet whole; do not crush, chew, or split it. Take exactly as prescribed by your doctor.

Tramadol acts as a weak mu-opioid receptor agonist. It also inhibits the reuptake of norepinephrine and serotonin, which contributes to its analgesic effect.

• •Hypersensitivity to tramadol or any component of the formulation.
• •Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic drugs.
• •Severe respiratory depression.
• •In patients with a history of seizures not adequately controlled.
• •Concomitant use with MAO inhibitors or within 14 days of discontinuing them.

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and sometimes circulatory collapse, hypotension, and death. Seizures have also been reported. Treatment includes maintaining a patent airway, providing assisted ventilation, and administering naloxone for opioid reversal. Gastric lavage may be considered.

Not recommended during pregnancy unless benefits outweigh risks, due to potential for neonatal opioid withdrawal syndrome. Tramadol is excreted into breast milk; use during lactation should be avoided.