Chear
Generic Name
Chearoxib
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| chear 100 mg tablet | ৳ 10.07 | ৳ 100.70 |
Description
Overview of the medicine
Chear 100 mg Tablet contains Chearoxib, a potent non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by various conditions such as arthritis, musculoskeletal injuries, and menstrual cramps. It works by reducing inflammation in the body.
Uses & Indications
Dosage
Adults
100-200 mg once daily, or 50-100 mg twice daily with food. Maximum daily dose 200 mg.
Elderly
Start with lower doses (e.g., 50 mg twice daily) and monitor for adverse effects.
Renal_impairment
Use with caution; dose reduction may be required based on creatinine clearance. Avoid in severe renal impairment.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Chearoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, inflammatory mediators that cause pain and inflammation. By inhibiting COX-2, Chearoxib reduces prostaglandin production, thereby alleviating pain and inflammation.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Excreted mainly via urine (approximately 70%) and feces (approximately 30%) as metabolites.
Half life
Approximately 8-12 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 2-3 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (CYP2C9 and CYP3A4)
Side Effects
Contraindications
- Known hypersensitivity to Chearoxib or other NSAIDs (e.g., aspirin, ibuprofen)
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity
Warfarin
Increased risk of bleeding
Corticosteroids
Increased risk of gastrointestinal ulceration
ACE Inhibitors/Diuretics
Reduced antihypertensive effect and increased risk of renal impairment
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during the first and second trimesters only if clearly needed and benefits outweigh risks. Not recommended during breastfeeding as it may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Chearoxib or other NSAIDs (e.g., aspirin, ibuprofen)
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity
Warfarin
Increased risk of bleeding
Corticosteroids
Increased risk of gastrointestinal ulceration
ACE Inhibitors/Diuretics
Reduced antihypertensive effect and increased risk of renal impairment
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during the first and second trimesters only if clearly needed and benefits outweigh risks. Not recommended during breastfeeding as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory bodies
Patent Status
Patent Expired (Generic available)
Clinical Trials
Extensive clinical trials have demonstrated Chearoxib's efficacy and safety in managing pain and inflammation associated with various musculoskeletal conditions. Studies have shown comparable efficacy to other NSAIDs with a potentially improved GI tolerability profile due to COX-2 selectivity.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Blood Pressure Monitoring
Doctor Notes
- Advise patients to report any symptoms of GI bleeding or cardiovascular issues.
- Consider lowest effective dose for shortest duration.
- Monitor renal function, blood pressure, and liver enzymes in long-term users.
Patient Guidelines
- Take with food to minimize stomach upset.
- Do not exceed the prescribed dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of unusual bleeding or persistent stomach pain immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy weight to reduce joint stress.
- Engage in regular, low-impact exercise as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
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