Chear
Generic Name
Chear-50-mg-tablet
Manufacturer
Pharma Innovations Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| chear 50 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Chear 50 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) primarily used for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis, and for the management of acute pain. It works by reducing inflammation and pain.
Uses & Indications
Dosage
Adults
For osteoarthritis and rheumatoid arthritis: 50 mg once daily. For acute pain: 50 mg as a single dose, or 50 mg twice daily if needed.
Elderly
Usually no dosage adjustment is required, but caution is advised due to increased risk of adverse effects.
Renal_impairment
Initial dose reduction to 50 mg every other day may be considered for severe impairment (CrCl < 30 mL/min). Not recommended for severe renal disease.
How to Take
Administer orally, with or without food. Taking it with food may reduce gastrointestinal discomfort.
Mechanism of Action
Chear selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain and inflammation. By inhibiting COX-2, it reduces the production of these inflammatory prostaglandins, thereby providing anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Within 1 hour for pain relief, but full anti-inflammatory effects may take several days.
Excretion
Excreted predominantly in the urine (about 27%) and feces (about 57%) as metabolites; less than 1% as unchanged drug.
Half life
Approximately 8-12 hours.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in approximately 2-4 hours after oral administration.
Metabolism
Primarily hepatic via cytochrome P450 (CYP2C9) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to chear or other NSAIDs
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Active gastrointestinal bleeding or peptic ulcer
- •Severe heart failure
- •Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels
Warfarin
Increased risk of bleeding
Methotrexate
Increased methotrexate toxicity
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management includes symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Not recommended in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use during early pregnancy and lactation only if clearly needed and benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
DGDA approved
Patent Status
Patent expired (generic available)
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Global Brand Names
International brand names for this medicine
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