Cinamycin
Generic Name
Cinamycin 300 mg Capsule
Manufacturer
Global Pharma Inc.
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cinamycin 300 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Cinamycin 300 mg Capsule is a macrolide antibiotic used to treat a wide range of bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
300 mg once daily for 3-7 days, depending on the infection. For specific infections, dosage may vary.
Elderly
No dosage adjustment is generally required, but monitor for adverse effects due to potential age-related decline in renal/hepatic function.
Renal_impairment
Mild to moderate impairment: No dosage adjustment. Severe impairment (CrCl < 30 mL/min): Exercise caution, consider dose reduction.
How to Take
Take the capsule orally with a glass of water, with or without food. Do not chew or crush the capsule. Complete the full course of treatment as prescribed by your doctor.
Mechanism of Action
Cinamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby preventing translocation of peptide chains. This action typically results in a bacteriostatic effect.
Pharmacokinetics
Onset
Within 2-4 hours of administration.
Excretion
Mainly excreted in the bile and feces, with a small amount excreted unchanged in urine.
Half life
Approximately 10-15 hours, allowing for once or twice daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract, bioavailability of approximately 60-70%. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Primarily metabolized in the liver via CYP3A4 enzymes to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to cinamycin or any other macrolide antibiotic.
- Patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior cinamycin use.
- Concomitant use with drugs known to prolong the QT interval (e.g., cisapride, pimozide).
Drug Interactions
Digoxin
Increased serum digoxin levels, monitor digoxin concentrations.
Warfarin
Increased anticoagulant effect, monitor INR.
CYP3A4 Inhibitors/Inducers
May alter cinamycin metabolism.
Statins (e.g., Simvastatin)
Increased risk of myopathy and rhabdomyolysis.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include severe nausea, vomiting, diarrhea, and abdominal discomfort. Management involves symptomatic and supportive treatment, including gastric lavage and general supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised when administering to a nursing mother. Consult your doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to cinamycin or any other macrolide antibiotic.
- Patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior cinamycin use.
- Concomitant use with drugs known to prolong the QT interval (e.g., cisapride, pimozide).
Drug Interactions
Digoxin
Increased serum digoxin levels, monitor digoxin concentrations.
Warfarin
Increased anticoagulant effect, monitor INR.
CYP3A4 Inhibitors/Inducers
May alter cinamycin metabolism.
Statins (e.g., Simvastatin)
Increased risk of myopathy and rhabdomyolysis.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include severe nausea, vomiting, diarrhea, and abdominal discomfort. Management involves symptomatic and supportive treatment, including gastric lavage and general supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised when administering to a nursing mother. Consult your doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA and DGDA
Patent Status
Patent protected
WHO Essential Medicine
YesClinical Trials
Cinamycin has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety. Post-marketing surveillance (Phase IV) is ongoing to further evaluate long-term effects and rare adverse events.
Lab Monitoring
- Liver function tests (LFTs) if treatment duration is prolonged or in patients with pre-existing hepatic impairment.
- Renal function tests in patients with severe renal impairment.
- ECG monitoring in patients at risk for QT prolongation.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent resistance and ensure eradication of infection.
- Counsel patients on potential drug interactions, especially with warfarin, digoxin, and statins.
- Advise patients to report any signs of hypersensitivity or severe gastrointestinal symptoms promptly.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if you feel better.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor immediately.
- Avoid concurrent use of antacids containing aluminum or magnesium within 2 hours of taking cinamycin.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cinamycin may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during treatment as it may exacerbate side effects.
- Ensure adequate rest to aid recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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