Cinamycin
Generic Name
Cinamycin
Manufacturer
Global Pharma
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cinamycin 300 mg injection | ৳ 40.00 | N/A |
Description
Overview of the medicine
Cinamycin 300 mg Injection is a broad-spectrum macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
300 mg intramuscularly once daily for 5-7 days.
Elderly
No specific dose adjustment required unless significant renal or hepatic impairment.
Renal_impairment
Dose reduction advised for creatinine clearance <30 mL/min.
How to Take
Administer intramuscularly into a large muscle mass. Do not administer intravenously as a bolus.
Mechanism of Action
Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
Pharmacokinetics
Onset
Within 30 minutes for therapeutic effect.
Excretion
Mainly biliary, with a small portion excreted renally.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed after intramuscular administration, achieving peak plasma concentrations within 1-2 hours.
Metabolism
Primarily hepatic via CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to macrolide antibiotics
- History of cholestatic jaundice/hepatic dysfunction associated with previous cinamycin therapy
Drug Interactions
Digoxin
May increase digoxin levels, requiring monitoring.
Warfarin
May enhance anticoagulant effect, increasing bleeding risk.
Statins (e.g., Simvastatin)
Increased risk of myopathy and rhabdomyolysis due to CYP3A4 inhibition.
Storage
Store below 25°C, protect from light. Do not freeze.
Overdose
Symptoms may include severe gastrointestinal upset, hearing loss, and liver dysfunction. Treatment is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Category B for pregnancy. Use only if clearly needed. Excreted in breast milk, use with caution.
Side Effects
Contraindications
- Hypersensitivity to macrolide antibiotics
- History of cholestatic jaundice/hepatic dysfunction associated with previous cinamycin therapy
Drug Interactions
Digoxin
May increase digoxin levels, requiring monitoring.
Warfarin
May enhance anticoagulant effect, increasing bleeding risk.
Statins (e.g., Simvastatin)
Increased risk of myopathy and rhabdomyolysis due to CYP3A4 inhibition.
Storage
Store below 25°C, protect from light. Do not freeze.
Overdose
Symptoms may include severe gastrointestinal upset, hearing loss, and liver dysfunction. Treatment is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Category B for pregnancy. Use only if clearly needed. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Multiple Phase III trials demonstrated efficacy against respiratory and skin infections. Ongoing post-marketing surveillance.
Lab Monitoring
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- ECG monitoring for QT prolongation (in high-risk patients)
Doctor Notes
- Monitor for signs of hepatotoxicity and QT prolongation.
- Counsel patients on completing the full course to prevent resistance.
- Consider culture and sensitivity testing before initiating therapy for severe infections.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Report any severe diarrhea or signs of allergic reaction immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer as soon as remembered. If it is close to the next scheduled dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment.
- Rest sufficiently to aid recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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